Dissertation > Excellent graduate degree dissertation topics show

Study of the Relation between Gastric Injury and Its COX-2 Expression after Abdominal Intestinal Firearm Wound in Pigs

Author: ShiYanHui
Tutor: WangYunHai
School: Xinjiang Medical University
Course: Surgery
Keywords: Cyclooxygenase-2 Intestinal perforation Stomach injury Endotoxin
CLC: R82
Type: Master's thesis
Year: 2010
Downloads: 5
Quote: 0
Read: Download Dissertation

Abstract


Objective:To investigate the changes of gastric tissue COX-2 after intestinal perforations due to abdominal firearm wound. And to study its relationship with plasma endotoxin levels and pathological change of gastric tissue. Methods:A total of 42 Chang-Bai piglets were assigned randomly into 7 groups:control group and wounded 1,2,4,8,12,24 hours group.The model of intestinal perforations due to abdominal firearm wound was established in wounded groups.Gastric tissue COX-2 activity was measured with immunohistochemical s taining and image analys is in all groups.The plasma endotoxin levels were measured by chromogenic limulus amebocyte lysate test.The alterations of gastric tissue were observed under light microscope in all groups.Results:The expressions of COX-2 of gastric tissue in wounded groups were significantly increased compared with control group(P<0.05).Plasma endotoxin levels of the experimental group were significantly higher than that of control group (P<0.05),and the peak appeared from 8h to 12h after injury.The experimental group appeared gradually aggravated gas- tric mucosa hyperemia and edema under light microscope. Inflammatory cell infiltration and subs- erous hemorrhage appeared in 12h and 24h group. Conclusion: The expression of COX-2 in gastric tissue is increased while the change of gastric injury isaggravated with prolongation of wound after intestinal perforations due to abdominal firearm wound, which suggests that COX-2 may play an important role in gastric injury of pigs.

Related Dissertations

  1. Treatment effect and its mechanism of lactose derivatives Gu- 4 in endotoxin shock in mice,R459.7
  2. Exogenous PCr anti- animal brain ischemia-reperfusion injury and brain-derived experimental study MODS,R965
  3. LPS activation of complement on endothelial cells and the inhibition of complement on LPS- induced acute lung injury,R563.8
  4. Detection of Bacterial Endotoxin by Enzyme-linked Immunosorbent Assay and Immunosensor,R115
  5. Combined Use Direct Endotoxin Absorption and High Volume Hemofiltration on the Influence of Endothelial Cells,R459.7
  6. Study on the Corrlation Between Serum Cytokines and Liver Function and Mitochondrial Injury with Sepsis,R459.7
  7. The Correlation between COX-2 and Ang-2 Expression in Human Gratric Cancer and Its Role in Lymphangiogenesis,R735.2
  8. In Vivo Screening and Characterization of Peptides Specifically Binding to Vasculature of Liver from Mice with Septic Shock,R459.7
  9. The Protective Effects of Scutellarin on Human periodontal Ligament Cell,R781.4
  10. Preliminary Study on Drinking Water Endotoxin and Endotoxin Immunosensor,R123.1
  11. SPV for the protection of severe trauma - hemorrhagic shock effect of intestinal permeability,R641
  12. The Effect of Blocking Prostaglandin Synthesis on the Expression of Endogenous Opioid Peptides in Peripheral Inflammatory Tissues,R363
  13. Expression and Clinical Significance of COX-2 and PGE2 in Lumbar Disc Herniation,R681.53
  14. Study on Protective Roles of Bifidobacterium at Neonatal Rat Model of Necrotizing Enterocolitis,R371
  15. Identification and Functional Study of Binding Proteins That Interact with IP-10 Promoter in Mice with Endotoxic Shock,R363
  16. The Therapeutic Effects of Heparin on Acute lung Injury Induced by Endotoxin in Rats,R563
  17. Lymph plasma endotoxin shock in rats and its mechanism of intervention,R459.7
  18. The Combination Effect of Celecoxib and 5-Fu in Human Gastric Carcinoma Cell Line SGC7901,R735.2
  19. The Significance and Relevance between the Expressions of Hypoxia-inducible Factor-1α (HIF-1α) and Cylooxygenase-2 (COX-2) in Lumbar Disc Herniation,R681.53
  20. The Study of Relationship between Hepatic Sympathetic Regulation and Acute Liver Injury,R363

CLC: > Medicine, health > Of Medical > Military Medical
© 2012 www.DissertationTopic.Net  Mobile