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Background: With the social development and economic progress, the human way of life (such as transport upgrades transition) as well as the living environment gradually changes, at the same time, the increasing number of traumatic brain injury (traumatic brain injury, TBI) patients with relevant The data show that the traumatic brain injury accounts for two of the various parts of the body trauma, mortality and disability rate as high as 30% -50%, ranking the first one. The study found that traumatic brain injury in the blood of patients after myocardial enzymes aspartate aminotransferase (AST), lactate dehydrogenase (LDH), alpha-hydroxybutyrate dehydrogenase (HBDH), creatine kinase (CK), creatine kinase workers enzyme (CK-MB) and troponin I corresponding increase occurs. Hypothermia treatment can reduce brain oxygen consumption, has a significant protective effect of traumatic brain injury patients with intracranial environment. The significant difference between patients with traumatic brain injury myocardial enzymes control group, mild hypothermia treatment of traumatic brain injury patients with myocardial enzymes changes any impact, we need to explore further. Objective: In this study, the treatment of traumatic brain injury patients with myocardial enzymes changes and clinical significance of hypothermia provide some experimental evidence to verify that mild hypothermia treatment of traumatic brain injury whether there are certain advantages, for mild hypothermia in clinical provide a theoretical basis for further application. Content: (1) studies of hypothermia in the treatment of traumatic brain injury patients with blood aspartate aminotransferase, lactate dehydrogenase, alpha-hydroxybutyrate dehydrogenase, creatine kinase, creatine kinase and troponin I change the impact; (2) to study the impact of hypothermia on intracranial pressure values ??and traumatic brain injury stove area. Methods: patients with traumatic brain injury (GCS ≦ 8) 63 cases, the patients were randomly divided into mild hypothermia group and the control group, the hypothermia treatment within 12 to 24 hours after the trauma of the hypothermia treatment group of patients, to maintain rectal temperature at 32 -35 ℃, and then maintain the intracranial pressure to normal levels for 24 h the hypothermia treatment time is 3-5 days. Normothermic group drug treatment hypothermia treatment group detected the following indicators: Record O, 1, 3, 5, 7 d intracranial pressure values ??and traumatic brain injury brain edema area; using the Hitachi 7180 type \1, 2, 3, 4 and 5 days after the onset of traumatic brain injury and on the sharp ordinary myocardial infarction instrument vein trend myocardial enzymes. Results: In the entire treatment period, mild hypothermia group, aspartate aminotransferase, lactate dehydrogenase, compared with normal body temperature, no significant differences (P gt; 0.05), three days after traumatic brain injury, alpha-hydroxybutyrate dehydrogenase, creatine kinase, creatine kinase MB, troponin with normal body temperature groups are compared, there is a significant difference (P lt; 0.05). Conclusions: Mild hypothermia can improve patients with traumatic brain injury, myocardial enzymes, reduce the degree of myocardial injury after traumatic brain injury, reduce complications, and help to improve the prognosis of patients with traumatic brain injury.
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