Dissertation > Excellent graduate degree dissertation topics show

The Meaning of Diagnosis about TCR and IgH Gene Rearrangements in T-lymphocyte Infiltration with Epidermotropism Disease

Author: SunLiangLiang
Tutor: PuXiongMing
School: Shihezi University
Course: Pathology and Pathophysiology
Keywords: Pro epidermoid Mycosis fungoides TCR gene TCR gene rearrangements IgH gene rearrangement
CLC: R739.5
Type: Master's thesis
Year: 2010
Downloads: 11
Quote: 0
Read: Download Dissertation

Abstract


Objective: To identify TCRγ gene rearrangement in the diagnosis of mycosis fungoides significance of specific applications, TCRγ and IgH gene rearrangement explore the mushroom-like the granuloma and vice psoriasis occur between the development of related research, research TCRγ and IgH gene rearrangement in the importance of joint application in the differential diagnosis of the clinical diagnosis, and to explore the significance TCRγ and IgH gene rearrangement in T lymphocytes the infiltration pro epidermal disease diagnosis. Methods: Using immunohistochemical methods to filter out 17 cases of T lymphocytes histopathologic diagnosis of mycosis fungoides, suspected 32 cases, 10 cases of vice psoriasis and eczema, 10 cases of mycosis fungoides, and then use the phenol - chloroform mycosis fungoides screening of the Xinjiang Uygur Autonomous Region People's Hospital, Department of Dermatology, collected by the group, suspected mycosis fungoides, Vice psoriasis and eczema, paraffin-embedded tissue for DNA extraction and polymerase chain PCR amplified mycosis fungoides, suspected mycosis fungoides, vice psoriasis and eczema gene fragment. Results: (1) confirmed 17 cases of mycosis fungoides in nine cases TCRγ gene rearrangement is positive, the positive rate was 52.94%; five cases IgH gene rearrangement positive, the positive rate was 29.41%; (2) suspected of 32 two cases of patients with mycosis fungoides TCRγ gene rearrangement was positive, the positive rate was 6.25%; 14 cases IgH gene rearrangement positive, the positive rate was 43.75%; (3) 10 cases, deputy psoriasis TCRγ gene rearrangement All the was negative; 4 cases IgH gene rearrangement positive, the positive rate was 40%. (4) 10 cases of eczema TCRγ gene rearrangement and IgH gene rearrangements were negative. Conclusion: (1) 17 patients with histopathologic diagnosis of mycosis fungoides TCR gene rearrangement positive in 9 cases, the positive rate was 52.94%, TCR and IgH gene rearrangements can be used for auxiliary diagnosis of suspected mycosis fungoides and differential diagnosis of a malignant lymphoma, and follow-up of some significance. (2) 32 patients with suspected mycosis fungoides two cases of TCR gene rearrangement positive, the positive rate was 6.25%, 14 patients had the IgH positive gene rearrangement, can be used for the diagnosis and identified from suspected malignant lymphoma, follow-up is more important. 4 cases (3) Vice psoriasis IgH gene rearrangement positive, such results may experiment in cross-contamination, Vice psoriasis may be associated with malignant lymphoma of the skin in the development of the process there is no obvious correlation The follow-up to this important value. (4) can be used as an important means to identify benign disease and malignant lymphoma gene rearrangement, provides some basis in patients with early diagnosis, early treatment and prevention of recurrence, thereby improving the quality of life of patients and important theoretical and practical significance.

Related Dissertations

  1. Detection of Bcl-2/IgH and IgH Rearrangements in Peripheral and Bone Marrow Lymphocytes of the Patients with Non-Hodgkin Lymphoma,R733.1
  2. Chronic lymphocytic leukemia IgH gene rearrangement and serum sCD23 TPO research,R733.7
  3. Effect of Immune Response Induced by APL Cells and PML-RARα Vaccine in Vitro and in Vivo,R733.71
  4. Investigating Genetic Damage of Workers Occupationally Exposed to Methotrexate and Vincrisitine,R131
  5. The Research of Specific T Cells Immunological Reaction and DNA Vaccine Construction Based on PML-RARα Fusion Gene,R392
  6. Study on the Correlation of Protein Expression and IgH Gene Rearrangement with the Subgroups of DLBCL,R733.1
  7. Detecting Genetic Damage of Human Lymphocytes Induced by Vincristine Using Four Assays in Vitro,R114
  8. A Study of Primary Cutaneous CD30+ Lymphoproliferative Disease on Clinicopathologic Features, TCR Gene Rearrangements and JunB Expression,R758.6
  9. Characterization of TCR γ Gene Rearrangement of T Cell Lymphomas and Its Detection Methods Improvement,R733.1
  10. A Clinical and Proteomic Study of Mycosis Fungoides,R739.5
  11. EB virus and human T-cell leukemia virus and the pathogenesis of mycosis fungoides correlation,R739.5
  12. Mycosis fungoides related biomarker research,R739.5
  13. A Preliminary Study of Candiadate Tumor Markers PRDX1, PPIA, MnSOD and FABP5 for Mycosis Fungoides,R739.5
  14. Expressin of BSAP and Detection of Rearrangement of IgH Gene of H/RS Cell and Its Background Lymphocytes in Classical Hodgkin’s Lymphoma,R392
  15. Clinicophology of Mycosis Fungoides: a Study of 22 Cases,R739.5
  16. Study on Expression of Cyclooxygenase1, 2 in Lesions of Granuloma Fungoides,R739.5
  17. The Expression of Programmed Cell Death 4 and Ki67 Protein in Mycosis Fungoides of Different,R739.5
  18. Preliminary Study on the Association of the Relativity between HHV-8 and Non-kaposi’s Sarcomas,R739.5
  19. Expression and Significance of FOXP3 in Pityriasis Rosea, Lichen Planus, Large-Plaque Parapsoriasis and Mycosis Fungoides,R758.63
  20. The Expression of Programmed Cell Death 5 and P53 Protein in Mycosis Fungoides of Different Stages,R739.5

CLC: > Medicine, health > Oncology > Skin tumors
© 2012 www.DissertationTopic.Net  Mobile