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Objective: To evaluate the safety of laparoscopic hepatectomy (LH), feasibility and minimally invasive. Routine liver resection: April 2008 to November 2009 met the inclusion criteria, 45 patients were randomly divided into laparoscopic hepatectomy (LH) group and open liver resection (OH) group. Two groups were compared, the average length of the incision, operative time, blood loss, postoperative feeding time, postoperative pain medication dosage, postoperative hospital days, without complications, Wai-operative changes in body temperature and blood changes, surgery before and after humoral immunity (IgG, IgM, IgA, IgE), changes in cell-mediated immunity (T cell subsets). Results: ① LH group in incision length (4.27 ± 1.01cm), the amount of bleeding (75.00 ± 57.05m1) and OH groups incision length (25.94 ± 9.35cm), the amount of bleeding (212.50 ± 82.66m1) difference was statistically significant (P lt; 0.05); the LH operative time (139.09 ± 53.75min) OH group operative time (168.44 ± 28.15min) were compared between the two groups showed no significant difference (P gt; 0.05); ② LH group eating time (1.55 ± 0.68d ) compared with the OH group eating time (3.00 ± 0.36d) was statistically significant (P lt; 0.05) LH group were no complications OH group, 2 cases of bile leakage, and 1 patient had ascites, no deaths analgesic consumption (11.00 ± 11.36mg) and postoperative hospital stay (6.27 ± 1.84d); LH group pain in the OH group dosages (103.13 ± 37.50mg) and postoperative hospital stay (16.56 ± 7.00d) the difference was statistically significant (P lt; 0.05). Two sets of patient temperature ③ preoperative difference was not statistically significant (P gt; 0.05); body temperature of patients after surgery have different levels of elevated body temperature peak (LH group was 37.16 ± 0.41 ° C in the first two days after surgery, OH group (38.22 ± 0.33 ° C); LH group at postoperative day 1, day 2 was significantly higher than that before surgery, the difference was statistically significant (P lt; 0.05), three days LH group, body temperature returned to to a normal level, the first three days of the OH group were still fever (37.45 ± 0.49 ℃), 1, 2, 3 days after the body temperature was significantly higher than the LH group, the difference was statistically significant (P lt two groups of patients; 0.05). ④ preoperative white blood cell count (LH group, 5.89 ± 0.85, the OH group 6.356 ± 04.19) and neutrophil ratio (LH 60.98 ± 11.67 OH group was 55.60 ± 12.98) between the two groups was not statistically significance (P gt; 0.05), after the two groups were rapidly increased, the increase of which the OH group is significantly higher than the LH group, 1,2 days after two groups of white blood cell count between the two groups was statistically significant (P lt ; 0.05), three days after LH group indicators has become normal, OH group is still higher than the normal two groups humoral immune level ⑤ preoperative difference had no statistical significance (P gt; 0.05), the two groups after operation humoral immunity in LH group IgG (10.32 ± 2.46g / L) and the OH group IgG (7.39 ± 1.36 g / L) difference was statistically significant (P lt; 0.05), the cellular immune preoperative level difference was not statistically significance (P gt; 0.05), patients with abnormal T-cell subsets indicators compare differences without statistical significance (P gt; 0.05) Conclusion: In the appropriate case selection, laparoscopic liver resection has a small abdominal incision after pain, shorter hospital stay, and recovery activities of daily living faster and fewer complications, efficacy was significantly better than open surgery, is feasible and safe, effective, minimally invasive treatment.
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