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Study on Related Factors and Serum Il-1β, IL-6 Levels in Patients with Progressive Cerebral Infarction

Author: ChengJiang
Tutor: DuYanHui
School: Ningxia Medical University
Course: Neurology
Keywords: Progressive cerebral infarction Risk Factors Interleukin-1β Interleukin-6
CLC: R743.3
Type: Master's thesis
Year: 2010
Downloads: 43
Quote: 0
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Abstract


Objective The morbidity and mortality rates of progressive cerebral infarction are higher than ordinary infarction,and it is one of the important reasons that could affect the prognosis of patients and it is also the difficulty of the treatment of cerebrovascular disease. In this paper,we will analysis and comparison the related factors and serum IL-1β,IL-6 test results in patients with progressive cerebral infarction , explore the possible pathogenesis,so we can found some possible affected and risk factors about it,and provide some relevant informations for clinical early detection, prevention and treatment of progressive cerebral infarction.Methods 112 patients with acute cerebral infarction in hospital no more than three days were selected., from April 2008 to October 2009 ,at the Affiliated Hospital of Ningxia Medical University Department of Neurology. According to cerebral infarction whether progressed after admission,the patients were divided into PCI group,50 cases ,and non-progression group, 62 cases. Select another clinic 30 cases of healthy people as control group.Registering the general information in PCI group and non-progression group, including gender, age, national, history of hypertension, diabetes history, history of coronary heart disease and smoking, alcohol abuse history; Checked and recorded the laboratory indicators, including routine blood test, fasting glucose, triglyceride (TG), total cholesterol (TC), plasma fibrinogen (FIB) concentration, plasma homocysteine (Hcy) levels;Quantifying the neurological deficit level of patients on admission with U.S. National Institutes of Health Stroke Scale. Detected the serum IL-1β, IL-6 levels in each group with Double-antibody sandwich ELISA method. According to the infarct volume,112 cases were divided into large infarction group, middle infarction group and small infarction group,then compared the IL-1β, IL-6 serum levels and the percentage of progressive cerebral infarction in each group.Results 1.There were no significant difference in gender, age, national, history of hypertension, history of coronary heart disease and smoking, alcohol abuse history between PCI group and non-progression group (P﹥0.05); there were 11(22%) cases of diabetes in PCI group and 5(8%) cases in non-progression group, There was statistically significant difference between the two groups(P﹤0.05). There were 21 cases(42%)had a fever on admission in PCI group and 12 cases(19.5%)in non-progression group,and there was statistically significant difference between the two groups(P﹤0.01). The NIHSS score of PCI group was 12.26±3.80,and non-progression group was 9.87±2.21. PCI group was higher than non-progression group, There was statistically significant difference between the two groups(P﹤0.01). 2. There was not significant difference between PCI group and non-progression group in white blood cell count, platelet count, serum triglycerides, total cholesterol, blood urea nitrogen and creatinine. PCI group was higher than non-progression group in blood glucose, Plasma fibrinogen concentration and plasma homocysteine concentration, and there was statistically significant difference between the two groups(P﹤0.05). 3.The Serum IL-1β, IL-6 levels in PCI group and non-progression group were higher than the healthy control group, and PCI group was higher than non-progression group (P﹤0.05). 4.The Serum IL-1β, IL-6 levels in large infarction group was higher than in middle infarction group ,and middle infarction group was higher than small infarction group;The incidence of PCI in large infarction group was higher than in middle infarction group and small infarction group(P﹤0.0125).5.The incidence of the performance of early CT abnormalities and Large area cerebral infarction in PCI group were significantly higher than in non-progression group (P﹤ 0.05).Conclusions 1.History of diabetes, hyperglycemia, hyperfibrinogenemia, high homocysteinemia,and fervescence were risk factors of progressive cerebral infarction. 2. The serum IL-1β, IL-6 levels in patients with cerebral infarction were higher than those in healthy controls,and the serum IL-1β, IL-6 levels were positively correlated with infarction volume;Infarction in patients with larger volume had high incidence of PCI. 3.The serum levels of IL-1β, IL-6 in PCI group were higher than non-progression group, maybe they had early warning Significance for the progress of cerebral infarction. 4 . Occurrence rates of early CT abnormalities and large area cerebral infarction were high in patients with PCI,so dose the NIHSS score.we should close observe and actively therapy these patients.

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CLC: > Medicine, health > Neurology and psychiatry > Neurology > Cerebrovascular disease > Acute cerebrovascular disease ( stroke)
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