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This paper from β-( or γ-) pyridine carboxylic acid , ( + ) - trans- chrysanthemic acid and permethric acid starting, acylation, esterification isothiocyanate , and then with the substituted-2 - amino- pyrimidin- nucleophilic addition of 18 Synthesis unreported N'-( substituted pyrimidin-2 - yl )-N-β ( or γ-) - picoline thiourea (Ⅰ), (Ⅱ), 5个no reported in the literature N'-( substituted pyrimidin-2 - yl )-N-(+) - trans- chrysanthemum acyl thiourea (Ⅴ) and 5 have not been reported N'-( substituted pyrimidin-2 - yl ) - N- acyl thiourea Permethrinic (Ⅵ). With Br 2 as the oxidant , the N'-( substituted pyrimidin-2 - yl )-N-β-( or γ-) pyridine- Formyl thiourea (Ⅰ), (Ⅱ) oxidative cyclization were 14 of this have not been reported to obtain a 2-β-( or γ-) picolinic acid imide group -2H-1, 2,4 - thiadiazole and [2,3-a] pyrimidine (Ⅲ), ( Ⅳ). By IR, 1H NMR, MS and elemental analysis of these six series of target compounds were characterized , and their physical and chemical properties , spectral properties , reaction conditions , synthesis methods for a more systematic analysis and discussion. Target compound (Ⅰ), (Ⅱ), (Ⅲ), (Ⅳ), (Ⅴ), (Ⅵ) The structural formula is as follows : In the National Southern Pesticide Research Centre, Department of Shanghai base Bioassay (Ⅰ) ~ (Ⅳ) four series of herbicidal activity of the target compounds were preliminary test work on (Ⅴ) ~ (Ⅵ) two series of target compounds herbicidal , insecticidal , bactericidal three active universal screening preliminary work . The results showed that : (Ⅰ) ~ (Ⅳ) four part series of target compounds with high herbicidal activity , and for corn safer ; (Ⅴ) ~ (Ⅵ) two series of some target compounds both weed, insect , sterilization and other multiple effects.
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