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The Research of the Expression of Platelet-derived Growth Factor-d in Placenta and Peripheralblood of Patients with Severe Preeclampsia

Author: WuQin
Tutor: YangYin
School: Fujian Medical
Course: Obstetrics and Gynaecology
Keywords: Platelet-derived growth factor -D Preeclampsia Early-onset severe preeclampsia Placenta Atherosclerosis
CLC: R714.24
Type: Master's thesis
Year: 2010
Downloads: 16
Quote: 0
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Abstract


[Objective ] by detecting the normal late pregnant women with severe preeclampsia placenta and serum platelet-derived growth factor -D (PDGF-D) expression , to explore the relationship between PDGF-D with severe preeclampsia . Earlier hairstyle and late-onset severe preeclampsia serum and placental tissue expression of PDGF-D , the etiology and pathogenesis of early-onset severe preeclampsia . [ Method ] selected severe preeclampsia pregnant women, 40 cases ( 11 cases of early-onset and late-onset 29 cases ) as the case group ; over the same period 20 cases of pregnant women as a control group . Extract two groups of pregnant women, venous blood and placental tissue examination taken in the expulsion of the placenta after cesarean . By enzyme-linked immunosorbent assay (ELISA) assay severe preeclampsia ( study group ) and normal late pregnant women (control group) in the peripheral blood serum concentration of PDGF-D . 2 . Severe preeclampsia and normal late pregnant women placental tissue PDGF-D mRNA expression level was measured by real-time quantitative PCR (Realtime PCR) . [ Results ] . Severe preeclampsia group maternal serum concentration of PDGF-D , early-onset group : 571.59 ± 67.35pg/ml , late-onset group : 573.92 ± 51.24 pg / ml , compared with the normal pregnancy group (509.63 ± 49.99 pg / ml), the serum concentration increased, the difference was statistically significant ( P lt; 0.05 ) . Severe preeclampsia group of pregnant women placental expression of PDGF-D mRNA , early-onset group : 2.72 ± 1.60 , late-onset group : 2.77 ± 1.57 , and normal pregnancy group ( 1.93 ± 0.82 ) , increased expression of the difference was statistically significance ( P lt; 0.05 ) . Severe preeclampsia serum and placental tissue expression of PDGF-D level was positively correlated ( r = 0.328 , p lt ; 0.05) . Early onset severe preeclampsia and late- onset severe preeclampsia serum of PDGF- D concentrations and placental tissue PDGF - D expression levels compared , the difference was not statistically significance ( P gt ; 0.05) . [Conclusion] 1 . Elevated peripheral blood serum and placental tissue PDGF-D may be associated with the incidence of severe preeclampsia , may be involved in the pathophysiology of severe preeclampsia process . 2.PDGF-D expression differences in early-onset and late-onset severe preeclampsia , suggesting that the pathogenesis of both may exist in common .

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CLC: > Medicine, health > Obstetrics and Gynaecology > Obstetrics > Pathological pregnancy ( abnormal pregnancy ) > Gestosis
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