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ObjectiveTo understand the etiology and influencing factor of cervicitis in Chenzhou district by case-control study, and to provide provide a theoretical basis for clinical medication and disease surveillance.MethodsCervical secretions were obtained from 184 patients who are diagnosed in general gynecology outpatient clinics and women’s health treatment clinics of the Xiangnan college affiliated hospital in Chenzhou from Nov.2007 to Apr.2008. We detected Ct, Uu, Mh, Mg, Ng, HSV-2 and HPV by Culture and PCR methods. At the same time, we selected 128 women in an outpatient health checks and pre-pregnancy check as controls. Also we have kept record for survey, including the age, sex, marital status, the culture level and the infection sources, etc, which are relevant to the infection.Results1 General information for the studied populationWe selected 184 patients who are diagnosed of cervicitis as the studied population, aged from 18 to 39, average (26.80±5.31)years. The disease course is 2 to 648 days, average for 58 days.138 cases with symptoms of urethra irritation, thermalgia in vaginal orifice, increased leucorrhea, and hypogastralgia,116 patients had disparity cervical erosion.128 women were selected as concurrent control, average for (26.16±5.28)years.2 Etiological studies for cervicitis(1) The detection of pathogens in cervicitisOf 184 patients with cervicitis, the cause was found in 157 (85.33%) patients, however, only 39 women with pathogen positive (30.5%), there was statistically significant between the two groups (OR=5.985, P=0.000). Among the cervicitis patients, the percentage of Uu was significantly higher, followed by Ct and Ng, Mg, NG. Surprisingly, the detection rate of Uu was also high in the control group, flowed by Mg. Chi-square test and Fisher’s Exact Test showed the detection rate of Ct, Ng and Mh were statistically significant (P<0.05) and other pathogens were not. (2) PolyinfectionOf the 127 patients, there were two or more pathogens in mixed infections was 26 cases (14.13%), mixed infection with two pathogens is more common, Ct, Mg, NG, Mh, HSV-2 and HPV were common coexistmg infection pathogens. Uu mergering Ct (34.62%) was the most common. The mixed infection with three pathogens was 4 cases (15.38%). In the control group, only 1 case with Mg mergering HSV and,1 for Uu and Mg coinfection.(3) Clinical symptoms of Uu, Mg and Ct positive patientsAsymptomatic infection was 31 cases (53.45%) in 58 Uu-positive infections; Asymptomatic infection was 8 cases (50%) in 16 Mg-positive infections; Asymptomatic infection was 20 cases (46.51%) in 43 Ct-positive infections, asymptomatic in mixed infection with three pathogens was statistically insignificant (P>0.05).(4) Pathogens and cervical erosionThere were 96 cases with cervical erosion in this study (84 in the cervicitis group and 12 in the control). Pathogens were correlated to cervical erosion. Different pathogens caused different degree of erosion, CT infection, Uu and CT coinfection, or CT, NG and HPV coinfection were more server than other pathogens.3 Influencing factor of CervicitisUu, Ct, Mh, HSV, HPV infection were risk factor for cervicitis, and Ct was utmost. Contraceptives users were more easy to cervicitis occurrence than non (OR=13.375); unmarried women were 2.909 times of risk of cervicitis than married women. Unemployment women had cervicitis risk is that "other profession" of onset of 3.203 times (OR). Conclusion1. Most of patients with cervicitis in the out-clinic in Chenzhou were aged 21 to 30, married and with middle school educational level2. The Uu had a higher positive expression rate in patients with cervicitis, and 50%of them were asymptomatic carrier.14.13%cervicitis patients with two or more pathogens are mixed infections; Pathogens were correlated to the degree of cervical erosion;3. Infection Uu, Ct, Mh, HSV, HPV is a women who cervicitis risk factors. Marriage, unemployment, and contraceptive use etc with an cervicitis also have relations, the mechanism research further
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