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Lipoxin A4 Inhibits CTGF-induced Expreession of Integrin-linked Kinase in Human Renal Tubular Epithelial Cells

Author: TaoHuiZuo
Tutor: WuShengHua
School: Nanjing Medical University
Course: Pediatrics
Keywords: Lipoxin A4 Connective tissue growth factor Integrin-linked kinase Renaltubular epithelial cell Signal transductio
CLC: R692
Type: Master's thesis
Year: 2010
Downloads: 15
Quote: 0
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Abstract


Objective Connective tissue growth factor （CTGF） can inducethe expression of integrin-linked kinase （ILK） in human renal tubular epithelial cellline （HK-2）. In this study, we investigated the modulatory effect of lipoxin A4 （LXA4）on action of CTGF-induced ILK expression, and explored the mechanisms of theaction of LXA4. Methods Cultured HK-2 cells were stimulated with CTGF with orwithout pretreatment of LXA4. The expression of ILK mRNA was detected byRT-PCR. The expressions of ILK protein, p42/P44 mitogen-activated protein kinase（p42/44 MAPK）（also called ERK1/2） and phosphoinositide 3-kinase （PI3-K） weredetected by Western blot. Results CTGF up-regulated the mRNA and proteinexpressions of ILK, and up-regulated the expression of phospho-ERK1/2 andphospho-PI3-K. LXA4 dose-dependently inhibited the above action of CTGF.Conclusion LXA4 inhibits CTGF-induced expression of ILK via ERK1/2 andPI3-K-dependent signal pathway.

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CLC: > Medicine, health > Surgery > Urology ( urinary and reproductive system diseases) > Kidney disease
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