Dissertation > Excellent graduate degree dissertation topics show

Studies on Similarity Evaluation of Chromatographic Fingerprint for TCM

Author: QiaoShanLei
Tutor: ChaiYiFeng；LiuLiLi；XuXu
School: Second Military Medical University
Course: Pharmaceutical Analysis
Keywords: chromatgraphic fingerprint TCM similarity retention time align peak matching
CLC: R28
Type: Master's thesis
Year: 2004
Downloads: 726
Quote: 11
Read: Download Dissertation

Abstract


Part IChromatographic fingerprinting combined with similarity evaluation provides an effective solution for the modernization of TCM (traditional Chinese medicine) quality control at present. Our study ranges from the theoretical induction to the software programming, and then the experimental verification.Effects of different retention time correction formulae on linear shift, nonlinear shift and retention time delay are discussed. Single-point formula deals well only with linear shift. Dual-point formula is suitable for the correction of nonlinear shift and retention time delay. Multi-point formula, depending on the segmented linear approximation, turns out to be effective in correcting the nonlinear shift.Peak matching is one of the key steps in the software programming, which improve the reliability of similarity calculation. A new matching algorithm is put forwarded based on total peaks sorting.Sensitivity and stability of three formulae in calculating similarity, i.e., cosine, correlation coefficient and Euclidean distance, are compared. Sensitivity and stability of the similarity, calculated by cosine with the point-to-point and peak-to-peak data, are further contrasted through derivation. Cosine with the peak-to-peak data provides an effective approach resulting in a compromise between sensitivity and stability.Accordingly, a chromatographic fingerprinting workshop is developed. The software provides the function of similarity calculation, integrated with three pattern recognition modules, i.e., principle component analysis, cluster analysis and artificial neural network.

Related Dissertations

  1. Research on TCM and BICM Schemes of the Coded Modulation Technology,TN911.22
  2. Syntactic Features Based Pronoun Resolution,TP391.1
  3. Research of Multiple Emails Automatic Summarization,TP391.1
  4. Research of IRC Botnet Detection Based on Behavior,TP393.08
  5. Chronic obstructive pulmonary disease osteoporosis and TCM kidney deficiency syndrome research,R259
  6. Isolated systolic hypertension in patients with cardiac ultrasound characteristics of traditional Chinese medicine dialectical correlation exploration,R544.1
  7. C-reactive protein,homocysteine ??levels in type 2 diabetic peripheral neuropathy of TCM,R259
  8. Medical interventions for patients with chronic heart failure heart rate variability,R259
  9. Integrative treatment of elderly patients with hypertension TCM syndromes and quality of life,R544.1
  10. Platelet parameters in patients before and after acute myocardial infarction,R542.22
  11. The Antioxidative Efficient Component Recognition for Curcuma Longa L. Based on the Quality Control Pattern of Constituent Knock-out/Knock-in,R285
  12. Research on Auto-Evaluation Method of Programming Based on Similarity,TP312.1
  13. Study of An Embedded Chinese Medical Therapeutic Apparatus,R197.39
  14. Comprehensive Evaluation of Flue-cured Tobacco Quality in Pingdingshan and Comparative Analysis with American Tobacco,S572
  15. Research on Relationship between Different TCM Dialectical Type and Associate with Sex Hormones and Risk Factors of Cardiovascular Disease in Perimenopausal Women of Hypertension,R259
  16. Retrospective Study on Pathological Results, Four Results of Liver Fiber, and TCM Syndrome Type of 164 CHB Patients,R259
  17. Research of the Different Syndrome Type of Idiopathic Thrombocytopenic Purpura to Glucocorticoid Sensitive Rate,R259
  18. The Clinical Analysis between the TCM Syndromes of Subacute Thyroiditis (Hyperthyroidism Stage),R259
  19. The Impact of Tourism on Typical Vegetation in Luya Mountain Nature Reserve, Shanxi Province,S759.9
  20. Clinical Study on Relationship Among Syndrome Differentiation Clssified in Tcm,ambulatory Blood Pressure Monitoring and Transcranial Doppler in Essential Hypertension,R259
  21. Shuganjianpi Decoction on type 2 diabetes and depression intervention clinical research,R259

CLC: > Medicine, health > Chinese Medicine > Of Pharmacy
© 2012 www.DissertationTopic.Net  Mobile