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The Application in Lumbar Intervertebral Disc of Young Volunteers with Magnetic Resonance T2* Map

Author: WangZuo
Tutor: LiuSiRun
School: Jinan University
Course: Biomedical Engineering
Keywords: T2 * map T2 * relaxation time values Lumbar disc Degeneration
CLC: R445.2
Type: Master's thesis
Year: 2010
Downloads: 40
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Abstract


Objective: The feasibility of the application in early lumbar disc degeneration by measuring youth volunteers lumbar disc marrow NMR T2 * relaxation time values ??, explore the T2 * map imaging technology . MATERIALS AND METHODS: select young volunteers from September 2007 to September 2009 , 40 cases of which : male 19 cases , 21 females , aged 18 to 30 years old , with an average age of 24.28 years old . All subjects, the volunteers had no low back pain and lumbar deformity / trauma / surgical history . GE Signa 1.5T HD magnetic resonance scanning instrument line L1 -S1 of T2WI and T2 * map scanning , GE-ADW4.2 processing workstation Functool software on the raw data are processed to generate T2 * pseudo color ( T2 * map ) . 5:00 ROI (region of interest), placed in the L1 / 2 ~ L5/S1 5 nucleus pulposus measure T2 * values ??. The data were statistically analyzed by SPSS16.0 package , single-factor analysis of variance (one-way ANOVA) lumbar disc within the disc nucleus pulposus T2 * values ??difference . Results : 1.T2 * value of the different regions in the same intradiscal differences ( P lt; 0.05 ) . 2.T2 * value of the corresponding region in the different disc plane differences ( P LT ; 0.05 ) . 3.L1 / 2 and L2 / 3 disc point ROI T2 * value was significantly higher (P lt; 0.05); L4 / 5, L5/S1 located in the nucleus pulposus central ROI T2 * values ??increased the most obvious (P lt ; 0.05) 4.T2 * values ??in the corresponding region in the different disc plane , with the lower position of the anatomical site and regularity of increments ( P LT ; 0.05 ) . Conclusion: 1 . The nucleus pulposus T2 * relaxation time values ??the space changes may reflect disc degeneration changes of the early water content and proteoglycan . The study measured T2 * values ??more consistent , and it reflects the changes of the biochemical composition of the nucleus pulposus and literature . 3.T2 * value may objectively reflect the nucleus pulposus degeneration characteristics embodied T2 * values ??and the correlation of the stress direction and anatomic site . 4.T2 * map imaging techniques have better sensitivity for early diagnosis of lumbar disc degeneration , early degeneration of intervertebral discs , as well as secondary injury may be forward-looking and quantitative evaluation of in vivo , non- invasive study of intervertebral disc degeneration the occurrence of mechanisms , early diagnosis , quantitative evaluation and efficacy evaluation of effective means for the prevention and treatment of lumbar disc degeneration positive clinical significance .

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CLC: > Medicine, health > Clinical > Diagnostics > Diagnostic Imaging > Magnetic resonance imaging
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