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Involvement of CRFR1 in Intermittent Hypoxia-exposed Neonatal Mice Spatial Learning and Memory

Author: WengJian
Tutor: DuJiZeng；ChenXueQun
School: Zhejiang University
Course: Neurobiology
Keywords: Hypoxia Learning and Memory Postnatal Development CRF CRFR1 IGFBP2 Hippocampal Stress
CLC: R33
Type: Master's thesis
Year: 2010
Downloads: 34
Quote: 0
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Abstract


Hypoxia (Hypoxia) is one of the organisms in natural activities may be subject to major stress , its biological development , behavior and health status , including humans , have an important impact . We have reported three or four weeks of moderate intermittent hypoxia (16% O2, 4 h / day ) of newborn mice spatial learning and memory , this spatial learning and memory capabilities and the level of phosphorylation of CREB and hippocampal CA1 region the LTP enhancement of pyramidal cells and hippocampal dendritic spine structural proteins SPAR and postsynaptic density protein PSD95 increases and other closely related . In this study, by real-time quantitative PCR , Elisa , pharmacology and behavior , hippocampal CRF and its receptor whether and how involved in the regulation of the mouse spatial learning and memory capabilities . The results of our study found that mice experienced intermittent hypoxia induced the P35 hippocampus CRF during development after birth , raised the CRFR1 and IGFBP2 expression ; also found that intermittent hypoxia can promote hippocampus IGFBP2 expression the IGFBP2 and SPAR was positively correlated kinds of role can be IGFBP2 antibody blocking . In addition , primary hippocampal neuron culture studies have shown that the 0.1nM CRF can promote IGFBP2 protein expression . The above findings mean that postnatal intermittent hypoxia raised the hippocampus of CRF , CRFR1 receptor increase a Ⅰ GFBP2 expression , thereby contributing to the structural protein of dendritic spines SPAR raised to enhance newborn mice spatial learning and memory .

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