Matrine suppositories in traditional Chinese medicine theory, under the guidance of the use of modern research techniques, combined with clinical practice, research product is m" />
Dissertation > Excellent graduate degree dissertation topics show

The Pharmaceutical Study on Total Alkaloids Suppiository

Author: DengXiangMin
Tutor: WangJianMing
School: Heilongjiang University of Traditional Chinese Medicine
Course: Chinese medicine
Keywords: Matrine Matrine Oxymatrine Suppository
CLC: R283
Type: Master's thesis
Year: 2010
Downloads: 136
Quote: 0
Read: Download Dissertation

Abstract


Matrine' dissertation">Matrine suppositories in traditional Chinese medicine theory, under the guidance of the use of modern research techniques, combined with clinical practice, research product is made of traditional Chinese medicine preparation by the the flavescens effective part matrine, heat dampness, kill the efficacy of the insect. After years of clinical practice has proved the matrine the suppository the cervical erosion, Chibai the vaginal discharge, trichomonas vaginitis and vaginal fungal infections and other gynecological chronic inflammation has a good effect. The purpose of this research is the effective parts of the Chinese herbal medicine Sophora matrine extraction method to improve, to achieve scientific extraction, making it more feasible in large-scale production; perfect matrine suppositories quality standards; visits bitter parameters the total alkali suppositories vitro release process and mechanism speculated that the drugs in vivo dissolution process reference; preliminary investigation of the stability of matrine suppositories. Experiment Resin extracted from Chinese herbal medicine Sophora matrine, matrine suppositories prepared by hot melt method and on this basis, with reference to the 2005 version of \Small batch trial results show that: the preparation process is reasonable and feasible, quality controlled. Experiment qualitative flavescens alkaloids identification of two methods of physico-chemical and thin layer at the same time, the use of acid-base titration method for the determination of total matrine in matrine suppositories HP1C Simultaneous determination of matrine and oxymatrine content Column: KR100-5NH2, Dimensions: (250mm × 4.6 mm, Nucleosil); mobile phase: acetonitrile - ethanol - double distilled water - phosphoric acid (80:14:6:0.2); flow rate 1.0ml · min-1 ; detection wavelength 220nm; column temperature was 25 ℃. The number of theoretical plates oxymatrine of not less than 2000; injection volume: 10μ1, using the external standard method by peak area. Matrine relationship good linearity in the range of 47.04 ~ 147.84μg · ml-1, r = 0.99985, oxymatrine linearly in the range of 38.64 ~ 121.44μg · ml-1 a ??good relationship, r = .99975; matrine average The recovery rate was 100.14%, RSD = 1.91% oxymatrine average recovery rate was 99.94% (RSD = 1.22%). Bromocresol green colorimetric this experimental in vitro release mechanism of matrine suppositories, the matrine the suppository vitro 30min fully released, the linear range of 9.87 to 99.46μg/ml (r = 0.9998), the average rate of recoveries of 99.49%, intra-day precision and inter-day precision of 1.85% and 2.62%, respectively. Retention samples at room temperature observation experiments on the stability of matrine suppositories, retention samples of the suppository analog commercially available packaging, 0,1,2,3 months stored at room temperature (20 ~ 25 ℃) were examined once. The results showed that the appearance of the shape of the product, identify, and the content of the inspection parameters had no significant change, quality basic stability of the formulation during storage. The issues in accordance with the guiding principles of drug research, specification matrine suppositories preparation process, improve the quality of matrine suppositories standard, laid the foundation for its quality standardization study.

Related Dissertations

  1. Matrine injection on the treatment of acute radiation enteritis and its mechanism,R285
  2. Nrf2, γ-GCS expression matrine bleomycin- induced pulmonary fibrosis,R285.5
  3. Clinical Study of the Treatment of PF with Matrine Injection,R285
  4. Clinical Research on the Effect of Matrine Soup on the Healing of Surgical Wounds of Anal Fistula,R285
  5. Study of a Gelrite/Alginate-based in Situ Gelling Ophthalmic Delivery System for Matrine,R283
  6. Connective Tissue Growth Factor, Nuclear Transcription Factor in Diabetic Rat Lung and the Intervention of Matrine,R285.5
  7. Study on Digitized Fingerprints of Radix Sophorae Flavescentis,R284
  8. Matrine Attenuates Pulmonary Arterial Hypertension Via Regulation ADMA/DDAH2 Signal Pathway and the Expression of eNOS,R285
  9. Preventive Effects of Matrine on Ventricular Remodeling of Chronic Heart Failure Rats and Its Molecular Mechanism,R285.5
  10. Matrine Injection Influences Serum IL-2、CD4~+、CD4~+/CD8~+ and Tumormarkers Levels of the Patients with Advanced Gastrointestinal Tumors,R285
  11. Protection of Matrine on Ischemic Neuronal Injury and Its Mechanism of Inhibition of NF-κB Signaling,R285.5
  12. Cellulose acetate and matrine release tablets,TQ461
  13. Study on the Adsorption Behaviors of Two Alkaloids on the Spherical Lignin Resin Absorbent,TQ464.4
  14. Inhibitory Effects of Matrine on Colorectal Carcinoma and Its Mechanism,R735.34
  15. The Effect of Matrine on MMP-1、TIMP-1 in Adriamycin-induced Glomerular Sclerosis Rat,R285.5
  16. Matrine on gastric precancerous lesions efficacy and mechanisms of susceptibility,R285.5
  17. Studies on the Botanicai Insectcides Controlling Poplar Pests,S763.7
  18. Comparative Study on Effects of HepG2 Cells in Vitro by Matrine and Oxymatrine,R735.7
  19. Protective Effects of Matrine on Immunological Liver Injury Induced by BCG and LPS in BALB/c Mice,R285.5
  20. Effects of Matrine and Sophoridine on Neural Plasticity,R285.5

CLC: > Medicine, health > Chinese Medicine > Of Pharmacy > Chinese medicine processing,preparation
© 2012 www.DissertationTopic.Net  Mobile