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Research of the Effect of PQS on the Expression of BDNF and GDNF in Cerebral Ischemia Rats

Author: LiZuoZuo
Tutor: SuYunMing；GuanLiXin
School: Heilongjiang University of Traditional Chinese Medicine
Course: Pharmacology
Keywords: Panax quinquefolius saponin Cerebral ischemia BDNF GDNF Neuroprotective effects
CLC: R285.5
Type: Master's thesis
Year: 2010
Downloads: 48
Quote: 0
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Abstract


Objective: To observe panax quinquefolius saponin (PQS) the neuroprotective effect of focal cerebral ischemia model in rat brain tissue , and to explore its mechanism . Method : using suture method is blocking one side of the brain of rats artery (MCAO), preparation of focal cerebral ischemia model , observed saponins of Panax quinquefolius 24h after MCAO rat model of cerebral ischemia and neurological deficit led behavior changes the pathomorphological changes by HE staining under light microscope , and enzyme-linked immunosorbent assay (ELISA) to detect the effects of BDNF and GDNF expression in brain tissue , in order to explore the American ginseng stems and leaves saponins on cerebral ischemia neuroprotection. Panax quinquefolius saponin Results: significant improvement in rats and neurobehavioral symptoms and morphological changes in cerebral ischemic tissue , promote the expression of BDNF and GDNF MCAO model in the rat brain . Conclusion : American ginseng stems and leaves saponins have neuroprotective effects on focal cerebral ischemia in rats , which may be related panax quinquefolius saponin for BDNF and GDNF expression in brain tissue .

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