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Objective: to study early in patients with cirrhosis observed fibrillation capsules affect its clinical efficacy , its stable liver function against liver fibrosis delay cirrhosis process mechanism to provide a reliable basis for clinical application . Methods: The clinical diagnosis of early cirrhosis of the 63 patients were randomly divided into two groups of 32 cases of Chinese medicine fibrillation capsule treatment group , rhubarb ( ?) The worm capsule control group, 31 cases , both groups 3 months for a course , symptom changes were observed before and after treatment , recorded scores of symptoms, signs , and detection the efficacy indicators : liver function parameters ( ALT , AST , GGT, ALP , ALB , A / G , TBil ) , cholinesterase (CHE ) The prothrombin activity degrees ( PTA ) , serum fibrosis markers ( hyaluronic acid ( HA ) , laminin protein ( LN ) type III procollagen (PC - III ) , and type IV collagen ( IV -C ) ) , serum etiological indicators and abdominal ultrasonography tests of liver fibrosis hemodynamic indicators ( portal vein inner diameter ( Dpv ) , spleen vein diameter ( Dsv ) portal vein blood flow the speed ( Vpv ) , portal blood flow ( Q ) , spleen thickness (st )) , abdominal ultrasound to check the liver and spleen ultrasound change indicators rated security monitoring of blood , urine , stool routine , ECG , renal function indicators were statistically analyzed to determine the efficacy and safety of drugs . Results: After 3 months of treatment , the two groups in overall efficacy , the efficacy of TCM symptoms and restore liver function, reduced liver fibrosis indicators improved imaging and other major indicators have clinical efficacy , but efficacy is better fibrillation capsule group , with rhubarb ( ? ) worm pill group were significantly different ( P lt; 0.05 ) . Conclusion : fibrillated capsule effective in the treatment of early cirrhosis reverse liver fibrosis , delay cirrhosis processes , worthy of further research and clinical application .
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