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Study of the Preparation Process of Sophora Flavescens Dispensing Granules and Its Quality Control

Author: JuJianYun
Tutor: ZhaoHaiXia
School: Shandong University of Traditional Chinese Medicine
Course: Of Pharmacy
Keywords: Of Sophora formula particles Preparation Process Quality Control
CLC: R283
Type: Master's thesis
Year: 2010
Downloads: 152
Quote: 0
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Abstract


Objective: To study flavescens Pieces optimum cutting process the Sophora water extraction and semi-bionic extraction optimize the extraction process comparison and both combined pharmacodynamic comparison, preferably the best preparation for the preparation flavescens recipe particles process, at the same time on fingerprints and particles fingerprinting and Sophora medicinal heavy metals and pesticide residues to provide some scientific basis in order to ensure the of Sophora formula particles industrial mass production, and to ensure the safety and effectiveness of its clinical drug. Methods: flavescens alkaloid content was measured by high performance liquid chromatography, preferred flavescens Pieces best cutting process, Sophora water extract method and semi-bionic extraction of optimum extraction process and the comparison between the two; flavescens herbs extracts and herbs to their formula particles pharmacodynamic comparison; fingerprints of Sophora herbs to their formula particles, using atomic absorption spectrometry flavescens herbs in copper, lead, cadmium content using atomic fluorescence spectrometry determination of arsenic mercury content, BHC, DDT content was determined by capillary gas chromatography, the complete the Sophora recipe particle system research. Results: 1. Determine the flavescens Pieces cut process: 0.7 times the amount of water to soak the herbs 3h, invasion 9h slices, cut thickness of 2 mm. Reflux extraction. Optimum extraction process to determine the the flavescens recipe particles water extraction: the Sophora Pieces with 10 times the amount of water to soak for half an hour after three times, each time 2h. Semi-bionic extraction flavescens formula particles is determined optimum extraction process of: three fried water for pH: 2.0,7.5,9.0; boiling time 2h, 1h, 0.5h, and the semi-bionic extraction than water formulation of good. Pharmacodynamic flavescens extract semi-bionic efficacy than water extract significantly flavescens water extraction no difference in the efficacy of the solution to their recipe particles. 5. Sophora medicinal herbs and their formulations particles fingerprints. The medicinal substance detection of heavy metals and pesticide residue content are in line with standards, there are some differences in the content of the different regions flavescens herbs. Conclusion: measured by the indicator ingredients of herbs combined with pharmacodynamic comprehensive preferred the Sophora recipe preparation process of the particles; through the development of the heavy metal content of particles fingerprint flavescens herbs and their formulations, and Sophora Radix pesticide residue content detection, and provides a basis for evaluation for the safe use of the Sophora formula particles.

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CLC: > Medicine, health > Chinese Medicine > Of Pharmacy > Chinese medicine processing,preparation
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