|
The high degree of oxidation of fulvic acid containing reactive functional groups (carboxyl, phenolic hydroxyl, quinone-based), and water-soluble, well absorbed by the body, are superior in terms of physico-chemical and biological activity in general humic acid, is the best one of the medical effects of humic acid. Thousands of years ago, Li in the \In recent years, there are many reports of fulvic acid and fulvic sodium anti-inflammatory, anti-virus, and regulation of immunity, anti-bacterial, anti-ulcer, have a significant effect certainly. According to Li Po, who proposed the Pu'er tea theabrowns and fulvic acid in chemical properties (structural and functional groups) there is a certain similarity between the fulvic acid in physiological activity and the treatment of certain diseases of the functional aspects of tea pigment should have similar Therefore, it can be speculated that the fulvic acid should have a sober, hypoglycemic function. This subject to successful modeling Kunming mice as experimental subjects, observed fulvic acid and fulvic sodium mouse model was successful hangover, lowering blood sugar. The main results are summarized as follows:. Xundian lignite as raw material, using hydrogen peroxide oxidation method to extract the preparation of crude fulvic acid; AB-8 macroporous resin column twice purified fulvic acid to reduce the ash content of fulvic acid, eventually get to a purity of 96.28% fulvic acid products. 2. Limits Examined fulvic acid and fulvic acute toxicity of sodium and fulvic acid-long drug experiments preliminary exploration, fulvic acid and fulvic sodium toxicity test results for the safety of medication necessarily reliable basis. Agilent gas chromatograph and the determination of the median lethal dose of ethanol, examine the fulvic acid mice ethanol acute poisoning prevention; ethology, experimental observation drunken time of the mice in each group, and the number of mice drunkenness; 30,60,90 min mice blood were measured after administration of ethanol changes. : Fulvic acid can reduce the mouse acute poisoning death number has obvious preventive effect of ethanol acute poisoning. Compared with the model group, 3%, 5% fulvic acid group mice drunken time was significantly shorter (P lt; 0.05); compared with Neptune Jinzun group, 1%, 3%, 5% fulvic acid group mice drunkenness time was significantly shorter (P lt; 0.05), and 5% fulvic acid hangover anti-drunk best. Compared with model group, 30,90 min, 1%, 5% fulvic acid groups in mouse plasma ethanol concentration decreased significantly (P lt; 0.05); 60min, reduce the concentration of ethanol was significantly (p lt; 0.01) . Compared with Neptune Jinzun group, 60,90 min, 1%, 5% fulvic acid group concentration of ethanol in the plasma of mice significantly reduced (P lt; 0.05). Experiment intraperitoneal injection of alloxan diabetic mice model investigated fulvic acid and fulvic acid sodium on blood glucose in normal mice, diabetic mice, oral glucose tolerance, and diabetes blood glucose, total cholesterol , triglycerides, and body weight. Results: high dose of fulvic acid and fulvic sodium can more significantly reduce normal blood glucose (P lt; 0.01);, high doses of fulvic acid and fulvic sodium can significantly lower the blood glucose in diabetic mice total cholesterol, triglyceride levels (p lt; 0.05 or p lt; 0.01), low-dose sodium fulvic \humic acid, high dose of fulvic acid and fulvic sodium significant effect (P lt; 0.05); oral glucose tolerance test, medium and high dose of fulvic acid and fulvic sodium can significantly lower weight gain in mice diabetic mice, blood glucose (p lt; 0.05). These results indicate that, fulvic acid and fulvic sodium hangover, hypoglycemic effect after fulvic acid and fulvic sodium in the field of medicine, further development and utilization of pharmacy.
|