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Preparation of Oral Cavity Pharmaceutics Granules of Effective Components of Bupleurum Chinense

Author: WeiXueGang
Tutor: ZhangChangGong
School: Huazhong University of Science and Technology
Course: Pharmacognosy
Keywords: Of Saikkosaponins Of Bupleurum volatile oil Solubilization β-cyclodextrin Inclusion
CLC: R283
Type: Master's thesis
Year: 2009
Downloads: 64
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Abstract


The Bupleurum volatile oils, saikosaponin the active ingredients the Bupleurum play major pharmacological effects. Traditional Bupleurum extraction process only take into account the volatile oil extract or saikosaponin, extract, a comprehensive extraction examine Bupleurum volatile oil of saikosaponin of has not been reported, to examine the experiment the Bupleurum volatile oil saikosaponin of integrated extraction process experimental conditions: soaking time (h), NaCl concentration (g / ml), and extracted as a comprehensive survey of indicators in order to the Bupleurum volatile oil extraction rate and saikosaponin extraction rate, to extract of Bupleurum volatile oil steam distillation time (h) orthogonal experiment to determine the optimum Bupleurum volatile oil extracted results: 6 times the amount of C3 concentration of NaCl solution T1 time to the water boiling extraction D3 time, extracting saikosaponin process eight times the amount of 70% ethanol, 80 ℃, reflux extraction, 1h /. This is to ensure that Bupleurum volatile oil extraction rate, but also can ensure saikosaponin the extraction rate to ensure comprehensive extraction efficiency and effective part of the extraction process more reasonable. Bupleurum volatile oil saikosaponin modern pharmacology has been proved to be the main active site in Bupleurum Bupleurum saponins and Chaihu of volatile oils compatibility, will play the synergistic effect of the two active site. Strong hemolytic activity saikosaponin, should not be made of injection, another saikosaponin is very unstable in strong acid environment in the gastric juice environment are prone to degradation, and should not be made formulations absorbed from the gastrointestinal tract; Bupleurum volatile oil been used in clinical form of injections, however gradually revealed many problems in recent years, for a quick play to their antipyretic, anti-bacterial, anti-inflammatory activity of the experimental increase saikosaponin Bupleurum volatile oil solubility and made oral preparations, drugs can directly absorbed through the oral mucosa to prevent the drug in the gastrointestinal tract is destroyed, and can also avoid the first-pass effect. This experiment by β-cyclodextrin (β-CYD) the inclusion of the volatile oil, both to improve the solubility of the the Bupleurum volatile oil, but also improves the stability of the the Bupleurum volatile oil, to make of Bupleurum volatile oil can be rapidly absorbed in the mouth and quickly The role of antipyretic and anti-inflammatory. The established UV-visible spectrophotometry the Bupleurum volatile oil inclusion rate method, Bupleurum volatile oil maximum absorption peak at 270nm, and good linearity. Bupleurum volatile oil and the rate of the indexes by orthogonal test and variance analysis to determine the best process of inclusion. The results are: of Bupleurum volatile oil with β-cyclodextrin clathrate mass ratio BB3, Bupleurum volatile oil is dissolved by a small amount of anhydrous ethanol, was slowly added to the already high temperature sufficiently dissolved concentration of A3 is β-cyclodextrin The spermatic solution, the temperature thermostat C3 stirred D2 time, remove the cooling to room temperature, placed in the refrigerator 10H, β-cyclodextrin sufficiently precipitate, filtered and dried an oven at 60 ° C. By thin layer and UV Mang.Formation identified determine Mang.Formation. Saikosaponin poor in the solubility in water, to increase its solubility, we used excipients M to be solubilized. Through single factor and orthogonal experiment to determine the optimal solubilization conditions of temperature magnetic stirring method. By HPLC saikosaponin a, d solubility., And carried out a methodological study. To the saikosaponin a d solubility as index, accessories M solubilization conditions by orthogonal results for: the of Saikkosaponins (purity gt; 50%) with accessories M quality than A2, a certain quality of Saikkosaponins samples, Sample by BB2-fold amount of 70% ethanol was dissolved, and then added slowly A2 times the amount of 0.1g/ml excipients M, C3 temperature thermostat was stirred for 1h, drying, grinding, sifting. The results show that the increased solubility Saikosaponin a 25-fold increase in solubility of saikosaponin d 52 times. Of saikosaponin solubilization for Bupleurum volatile oil clathrate prepared sheet material ready for the next step oral.

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CLC: > Medicine, health > Chinese Medicine > Of Pharmacy > Chinese medicine processing,preparation
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