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Extraction of Coptis Chinensis Franch Alkaloids and Hypoglycemic Activity Research

Author: YangYong
Tutor: LiXueGang
School: Southwestern University
Course: Medicinal Resources Chemistry
Keywords: Coptis Alkaloid extract Hypoglycemic model optimization Hypoglycemic activity
CLC: R285
Type: Master's thesis
Year: 2009
Downloads: 141
Quote: 3
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Abstract


Coptis fibrous roots as raw material , Coptis alkaloid extraction and separation processes , and a of antidiabetic model optimization and Coptis alkaloids hypoglycemic activity . The results are as follows: 1 study Coptis alkaloids separation process . Come of the Coptis to be the best extraction and separation conditions : 0.2% sulfuric acid leaching , the amount of solvent used just the Coptis to be completely submerged . Extract and to about pH 5.0 with lime . Then over the D101 resin column until the resin adsorption of the alkaloid . Eluted and then 75 % acidic methanol 5 times. Established hypoglycemic model , and worked out the optimal conditions to establish hypoglycemic model : 18 ~ 22 g Kunming mice fasted for 12 to 16 hours , and 90 mg / kg intravenous injection of alloxan . Mice physique , size appropriate dose adjustment. 3 studied the hypoglycemic activity of the of Coptis alkaloid family of drugs , that: high doses of Coptis total alkaloids has significant hypoglycemic effects , The Coptis original powder also have certain hypoglycemic effect .

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