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Objiective:To study the mechanism of YI-FEI-KANG-XIN capsule in patients with chronic pulmonary heart disease and to explore the effect of the serum level of platelet activating factor(PAF).To explore clinic curative effect of YI-FEI-KANG-XIN Capsule to the Chronic Pulmonary heart disease.Method:the 60 cases of patients with parative Group by stochastic process.These two groups of patients with CCP were given the routine treatment.Comparative Group would not take any Chinese medicine while Therapeutic Group take YI-FEI-KANG-XIN Capsule.to compare the changes of PAF,blood gas analysis (PaO2,PaCO2,SO2), RVPEP/AT between Therapeutic Group and Comparative Group.Result:Statistical signicance in the total response rate of Therapeutic Group (93.33%) compared with the Comparative Group (70%) (P< 0.05).After a course of treatment,the level of PAF,blood gas analysis and RVPEP/AT in Therapeutic Group were all significantly changed (P< 0.001,P < 0.01,P< 0.01). The level of PAF,blood gas analysis and RVPEP/AT in the Comparative Group were also significance changed (P<0.001,P<0.01,P< 0.01).After the treatment,statistical significance in the improvement of PAF, blood gas analysis and RVPEP/AT of Therapeutic Group and Comparative Group (P<0.05)Conclusion:The research indicated that YI-FEI-KANG-XIN Capsule could dramatically increas curative effect,improve hypoxia,decrease the level of PAF,delay the formation of pulmonary vascular remodeling and the development of pulmonary hypertension,therefore achieve the purpose of treatment of chronic pulmonary heart disease
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