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Oxcarbazepine (Oxcarbazepine, OCBZ) , carbamazepine (CBZ) , keto derivatives, compared with CBZ better tolerated and smaller liver drug metabolizing enzyme induction effect . Currently OCBZ in many countries as a new first-line antiepileptic drug alternative for clinical CBZ , to review literature synthesis method based on the synthesis of two methods oxcarbazepine . First, as the raw material to 5 - chloro - formyloxy -imino stilbene synthesized by bromide , a methoxy group , hydrolysis of 10 - methoxyimino stilbene . And optimization of each step of the reaction conditions, and overall yield of 49.4% . Second , and then to 10 - methoxyimino stilbene as a starting material , using two routes synthesis of oxcarbazepine . A line as follows: 10 - methoxyimino stilbene and sodium cyanate reaction under acidic conditions , and then by hydrolysis of the route of the synthesis of oxcarbazepine , mainly investigated the influence of various factors on the reaction yield in the condensation reaction and found that only by changing the reaction conditions , is difficult to obtain the objective compound. Another route : 10 - methoxyimino stilbene as raw material instead of the extremely toxic gas phosgene , phosgene secure solid to react , then ammoniated hydrolysis reaction synthesized oxcarbazepine and optimization of step reaction conditions, the 10 - methoxyimino diaminostilbene count , total yield of 52.2% : 5 - chloro - formyloxy -imino stilbene total yield was 25.8% . The route process is simple, easy to get raw materials , high yield, low cost , suitable for industrial production .
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