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Effects of Estradial Combined with Progesterone on Action Potential in Rabbit Sino-Atrial Node Cells

Author: ShiXinYan
Tutor: PaErHaTi
School: Xinjiang Medical University
Course: Physiology
Keywords: estradial progesterone sino-atrial node. action potential(AP) orthogonal design.
CLC: R541
Type: Master's thesis
Year: 2004
Downloads: 23
Quote: 0
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Abstract


Objective: To investigate the effects of estradiol combined with progesterone on action potential(AP) of rabbit sino-atrial node and to find the optimum dose on combined use. Methods: Using conventions glass microelectrode technique .The task included two parts: 1)adopting L/32(49) orthogonal design arrayed experiments and analyzed results. (2)We observed the effects of E2 combined with P on the response of SA node cells to high Ca2+(5mmol/L). Results: 1) E2 or P prolonded AP duration (APD20, APD50, APD90 and APD), RPT and DPT, slowed down the maximal rate of rise of phase 0(Vmax), decreased the action potential amplitude(APA). 2)There are interactive action between E2 and P, P can strengthen E2 in some degree. The optimum dose on combined use is E2P2(E2 combined with P in low doses). 3) E2P2 antagonized the effects of high Ca2+ on SA node cells. Conclusion:The results suggested that E2 or P maybe inhibit the K+ channels and the Ca+ channels. The combinations of E2 and P in clinical aplication should be low doses.

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CLC: > Medicine, health > Internal Medicine > Heart, blood vessels ( circulatory ) disease > Heart disease
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