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The Research on Electrochemical Behavior of Biological Small Molecule and Its Interaction with DNA

Author: LiZhiFeng
Tutor: KangJingWan；LuXiaoQuan
School: Northwest Normal University
Course: Analytical Chemistry
Keywords: 3-NBT Modified electrode Electiocatalysis Nano-α-Al2O3 Electrochemical parameters Behavior Morin DNA Interaction Electrochemical method Eu-Morin complex DNA Interaction Electrochemical
CLC: Q75
Type: Master's thesis
Year: 2005
Downloads: 151
Quote: 0
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Abstract


As we all know , the material basis of life information transfer deoxyribonucleic acid ( DNA' dissertation">DNA ) , the destruction of the DNA molecule is bound to create obstacles to the process of life , or even interrupted . For DNA and other molecules, the role of its research is an area of relatively active . The specific function of modified electrode and the emergence of some of small biomolecules electrochemical nature study became possible , providing data and technical support for the study of the interaction between DNA and further . The understanding of the mechanism of action between the small molecules and DNA can further design and development of certain drugs having a specific function . Electrochemical method' dissertation">Electrochemical method based on the conventional solution developed DNA - modified electrodes , such as low sample consumption , high sensitivity , shows a wide range of application prospects in DNA- related research areas are . This thesis consists of the following four parts : Part I: Summary of reviewed : the 1 DNA electrochemical and its interaction with small molecules ① DNA role of of electrochemical of ② DNA and substance molecules ; the 2 DNA electrochemical sensor ( 1 ) the DNA modified electrode preparation the hybridization indicator method ② ③ DNA electrochemical sensor application development , and to establish the basis of the established title . Part II: 3 - nitrobenzaldehyde thiosemicarbazone electrochemical behavior studies to polishing were prepared nano- modified glassy carbon electrode in nano Al 2 O 3 γ-Al 2 O 3 modified glassy carbon electrode ( NA / GCE) . Optimize the process of their preparation . Compared to bare glassy carbon electrode , the electrode 3 - nitrobenzaldehyde thiosemicarbazone (3-NBT) has good electrical catalytic the CV peak sensitivity is higher . By cyclic voltammetry method ( CV ) , differential pulse voltammetry (DPV ) the conventional pulse voltammetry (NPV), the potential jump -order timing Coulomb's law ( CC ) , eliminate voltammetry (EV) electrochemical method , for the first time to study the electrochemical properties of 3-NBT . The results showed that , on the NA / GCE ,3 - the NBT of redox free radical process for the two one- electron and a proton ( quasi - reversible process I and non- reversible process II ) . 3-NBT NA / GCE surface coverage Γ = of 1.62 × -9 mol cm -2 . Obtain the diffusion process I and process II

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