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An Experimental Study of the Effects of PPAR-γ Agonists on Acute Experimental Autoimmune Encephalomyelitis, in Rats

Author: YuanBaoYu
Tutor: QinXinYue
School: Chongqing Medical University
Course: Neurology
Keywords: Experimental autoimmune encephalomyelitis Tumor Necrosis Factor Calcium-activated neutral protease Peroxisome proliferator-activated receptor -γ Non-steroidal anti-inflammatory drugs ( ibuprofen )
CLC: R744
Type: Master's thesis
Year: 2005
Downloads: 70
Quote: 0
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Abstract


Purpose of multiple sclerosis (multiple sclerosis, MS) is a central nervous system of unknown etiology (central nervous system, CNS) chronic inflammatory demyelinating disease , clinically definite lack of effective treatment . In this study, experimental autoimmune encephalomyelitis (experimental autoimmune encephalomyelitis, EAE) animal model , the application of peroxisome proliferator activator receptor -γ (peroxisomeproliferator-actived receptor-γ, PPAR-γ) excited rosiglitazone and non-steroidal anti-inflammatory drugs (non-steroidal antiinflammatory drugs, NSAIDs) ibuprofen treatment of EAE rats , observed clinical manifestations of disease-causing animals , morbidity, by detecting the proinflammatory cytokines tumor necrosis factor -α (tumor necrosis factor-α, TNF-α) and calcium-activated neutral protease (Calpain) expression levels to explore PPAR-γ agonist rosiglitazone and non-steroidal anti-inflammatory drug ibuprofen in EAE in the efficacy and mechanism of action , in order to reverse the clinical treatment of multiple sclerosis difficult situation , provide a new method and experimental basis . Method ⑴ in guinea pig brain and spinal cord homogenate plus complete Freund's adjuvant (complete Freund'sadjuvant, CFA) as an antigen , Wistar rats given subcutaneous footpad , while in the dorsal intradermal injection Bordetella pertussis , rat EAE model . ⑵ The experimental animals were randomly divided into four groups , the normal control group , EAE model group , rosiglitazone treatment group and ibuprofen treatment groups 8 . From the first two days after immunization , the animals were given drug intervention . Rosiglitazone dose of 4mg · kg-1 · d-1; ibuprofen dose of 100mg · kg-1 · d-1 gavage treatment ; the other two groups with normal saline instead. ⑶ clinical manifestations observed in all animals , according to Koh score rating ; 18 days after immunization , all the animals were sacrificed , specimens of brain specimens. Part HE staining , which

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