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Discussion on the effect and mechanism of adiponectin on vascular endothelial function

Author: GeZuo
Tutor: DengHuaCong
School: Chongqing Medical University
Course: Internal Medicine
Keywords: adiponectin nitric oxide endothelin tumor necrosis factor endothelium vascular
CLC: R589.2
Type: Master's thesis
Year: 2005
Downloads: 127
Quote: 0
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Abstract


Objective To investigate the influence and the primary mechanisms of adiponectin on endothelial function. Methods Human umbilicus vein endothelial cells were cultured out of body and the release of NO ,ET-1 and activation of NOS under basic condition and harmful condition caused by TNF-α were observed respectively. Results ①Adiponectin didn`t change the NO, total NOS(p>0.05), but inhibit activation of iNOS(p<0.01) and increase activation of eNOS(p<0.01) dependent on PI-3K pathway and inhibit release of ET-1 independent on PI-3K pathway (p>0.05)under the basic condition②Adiponectin may inhibit TNF-α-induced activation of iNOS and release of NO and ET-1(p<0.01) dependent on NF-kB pathway. Adiponectin reverse TNF- α -induced inhibition of eNOS(p<0.01) independent on NF-kB pathway. Conclusion adiponectin can maintain normal endothelial function and protect endothelium against damage from TNF-α by effecting NOS,NO and ET-1

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CLC: > Medicine, health > Internal Medicine > Endocrine diseases and metabolic diseases > Metabolic diseases > Lipodystrophy
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