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Effects of Autologous Tumor Immune RNA on Patients with Esophageal Carcinoma after Operation

Author: TanGuoLiang
Tutor: LiBaoQing；LiuJunFeng
School: Hebei Medical University
Course: Surgery
Keywords: Esophageal Cancer Immune RNA Immune function Ag-NORs Flow cytometry
CLC: R735.1
Type: Master's thesis
Year: 2005
Downloads: 54
Quote: 0
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Abstract


Objective: esophageal cancer is a serious threat to human health, a common malignancy. Now that esophageal cancer is not a localized disease , but a local manifestation of systemic disease . With the development of the modern theory of tumor immunity , people began to notice the cancer patients often accompanied by immune dysfunction , surgery and general anesthesia can exacerbate immune dysfunction , presented to the treatment of esophageal cancer should be systemic viewpoint . Autologous tumor immune RNA (iRNA) as a systemic immune control of tumor treatment in the comprehensive treatment of esophageal cancer and more attention . iRNA is a kind of normal cells or animals to pass specific immune function of biological agents , it can be passed across species boundaries and the establishment of specific immunity . iRNA for tumor therapy many years of history , because of its immunity to pass information between different tumor with a specificity of tumor antigens without cross reactivity , limiting the therapeutic effect. Patients with esophageal cancer in animals immunized preparing autologous tumor tissue iRNA, theoretically can overcome these limitations , more allogeneic tumor iRNA is an ideal immunotherapy . This study examined patients with esophageal cancer before and after surgery and application of autologous tumor immunotherapy iRNA immune function changes ; observation autologous tumor iRNA recent survival rates for patients with esophageal cancer effects . Both before and after surgery in patients with esophageal cancer by monitoring changes in immune function , to further clarify the surgical effects on immune function , and attempt to iRNA anti-tumor mechanisms of closer understanding . Methods: This study object selected in March 2003 - August 2003 Fourth Hospital of Hebei Medical University, Thoracic Surgery, surgical treatment of esophageal cancer , preoperative endoscopic biopsy confirmed esophageal squamous cell carcinoma . Sixty patients were randomly divided into

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CLC: > Medicine, health > Oncology > Gastrointestinal Cancer > Esophageal tumors
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