Dissertation > Excellent graduate degree dissertation topics show

Activation of LXR by T0901317 Causes an Increases in DBP and CYP46 Expression and a Decrease in Aβ Level in Mouse Brains

Author: YangYuan
Tutor: JiangLingLing
School: Hebei Medical University
Course: Biochemistry and Molecular Biology
Keywords: Hepatic solitary Nuclear receptor D- bifunctional protein Cholesterol - 24S - hydroxylase Cholesterol beta - starch -like protein TO901317
CLC: R749.16
Type: Master's thesis
Year: 2005
Downloads: 71
Quote: 0
Read: Download Dissertation

Abstract


Purpose : the deposition of beta - amyloid protein (beta-amyloid peptide, Aβ) is a key factor for the development of Alzheimer's disease ( Alzheimer 's disease , AD ) . Studies have shown that Aβ generation and precipitation of cholesterol metabolism are closely related . Inhibit cholesterol synthesis, and can significantly reduce the generation of Aβ and the incidence of AD ; hypercholesterolemia can increase brain Aβ immunoreactivity . Therefore, in recent years , the relationship of brain cholesterol metabolism disorder and Aβ generation became a research focus. Nuclear receptor LXR (liver X-activated receptor) in the brain tissue , is a key regulator of sites that control brain cholesterol flux . TO901317 is a chemical synthetic LXR ligands . The study found that the binding of the ligand and LXR activation of the ATP cassette transporter (ATP-binding cassette transporter, ABC) ABCA1, ABCG1 cholesterol metabolism downstream genes, to maintain the balance of the brain cholesterol library . APP23 transgenic mice overall experiments and C57BL / 6 mouse neurons in cell culture experiments have shown : with TO901317 , 22R - hydroxy cholesterol activate LXR , ABCA1 expression increased Aβ levels drop . But the overall level of normal mice to be LXR agonist , brain Aβ how changes have not been reported . The brain cholesterol through the blood-brain barrier into the blood, converted into bile acids to the liver is an important way to maintain the balance of brain cholesterol . The study showed that the majority of brain cholesterol by cholesterol - 24S - hydroxylase (cholesterol-24S-hydroxylase, CYP46) neurons within its conversion to the 24S - hydroxy- cholesterol through the blood-brain barrier . Activate LXR promotes cholesterol from the cells

Related Dissertations

  1. Screening and Primary Study of Lactic Acid Bacterial for Cholesterol-Degrading,TS201.3
  2. The Value of MELD Score and Serum Total Cholesterol in Predicting the Prognsis of Patients with Decompensated Liver Cirrhosis Caused by Hepatitis B Virus,R575.2
  3. The Effect of Simvastatin to the Appswe/PS1dE9 Transgenic Mouse with High Cholesterol Diet,R589.2
  4. Xanthate Mediated Living Free Radical Polymerization of the Nonconjugated Vinyl Monomers,O631.5
  5. Study on the Association between CETP Gene Polymorphism and Cerebral Infarction of Han Population in Hunan Province,R743.33
  6. Research of the Effect of Dietary High-cholesterol Seafood on Lipid Metabolism in Animals,TS254.1
  7. A Study of Serum Sex Hormone and Serum Cholesterol Levels As Well as Their Correlation in Gallbladder Cholesterol Stone Patients,R657.4
  8. Immigration officers epidemiological study of risk factors of fatty liver,R575.5
  9. The Correlative Analysis of Hepatitis B with Gallbladder Cholesterol Polyps,R657.4
  10. Effects of Allicin on Cholesterol Exllusion and Expression of ABCG5 and ABCG8 in Intestinal Epithelial Cell,R285
  11. Probiotic Properties of Lactobacillus Plantarum K25 and Its Application in Cheese,TS252.1
  12. Study on Liposomes Modified with PEtOz-CHEMS Lipid-Derivatives,O631.3
  13. An Investigation between Abnormality of the Blood Vessel and Hemodynamics in Posterior Circulation Ischemia,R743.3
  14. The Correlation Between the Genetic of Lipid Metabolism and Gallstone,R657.4
  15. Study on the Correlation Between eGFR and Atherosclerosis in Non-dialysis Patients with Chronic Kidney Disease,R692
  16. Research of Correlation between Parathyroid Hormone, Parathyroid Hormone-related Protein, Free Calcium, Cholesterol in Plasma during the Formation of Cholesterol Gallstone,R657.4
  17. CYP3A5 gene polymorphism and lipid abnormalities Relationship,R589.2
  18. Collaborative Production of Probiotic Fermented Milk Fermented,TS252.1
  19. Suet refining and powder technology research,TS225.22
  20. Preparation and Study on Functional Components from Rice Bran,TS209
  21. Use of β-cyclodextrin to Decrease the Level of Cholesterol in Butter,TS221

CLC: > Medicine, health > Neurology and psychiatry > Psychiatry > Cerebral organic mental disorder > Elderly as early as possible the old disorder
© 2012 www.DissertationTopic.Net  Mobile