Dissertation > Excellent graduate degree dissertation topics show

Expression of COX-2, MMP-9 and E-Cad in Gastric Cancer

Author: GaoHong
Tutor: ZuoYueE
School: China Medical University
Course: Oncology
Keywords: Gastric carcinoma Cycloonase - 2 Matrix metalloproteinases - 9 Eptithelial cadherin Immunochemistry
CLC: R735.2
Type: Master's thesis
Year: 2005
Downloads: 95
Quote: 0
Read: Download Dissertation

Abstract


IntroductionGastric cancer is a highly incident malignant tumor with increased morbidity, especially in Asia. Gastric cancer is typically associated with a very poor prognosis and advanced stage at presentation. One important cause of the poor prognosis even after radical treatment is that we have no sensitive and specific tumor markers, which makes diagnosis rather difficult. And adjuvant therapy is necessary to improve the surgical results.ObjectiveTo evaluate the expression of COX - 2, MMP - 9, E - Cad and their relationship with clinicopathologic characteristics and prognostic significance in gastric cancer.Materials And MethodsThe subjects were 51 patients who underwent surgical excision and diagnosed with gastric cancer at The 1st Affiliated Hospital of CMU between April 1998 and March 1999. All the specimens were detected by the technique of the immunochemical SABC with polycolonal antibody COX - 2, MMP - 9 and E -Cad. For statistical analysis, the chi - square test were used. P value less than 0.05 was regarded as significant.Result1. The expression of cycloonase - 2 ( COX - 2 ) in gastric carcinoma tissues was present in 62.8% (32/51) and no COX -2 staining was detected in normal gastric tissues. There was significant relationship between the gastric cancer tissues and normal gastric tissues ( p <0.01). And the expression of COX -2 were highly correlated with depth of infiltration, lymph node metastasis, TNM stadium of gastric cancer, but no noticeable relation to the lower differentiation gastric cancer cell.2. The expression of matrix metalloproteinase -9(MMP -9) in gastric carcinoma tissues was detected in gastric carcinoma tissues of 76. 5 % (39/51) and of 13. 3% (2/15) the normal gastric tissues. There was significant relationship between the gastric cancer tissues and normal gastric tissues ( p < 0. 01) . The related factors with MMP - 9 expression were depth of infiltration, lymph node metastasis, TNM stadium of gastric cancer cell. The non - related factor with MMP - 9 expression were the lower differentiation gastric cancer cell.3. All the normal gastric tissues abundantly expressed eptithelial cadherin (E - Cad) , but expression of E - Cad was60. 8 % (31/51) in the gastric cancer group. There was significant relationship between the gastric cancer tissues and normal gastric tissues( p <0.01). The related factors with E - cadherin expression reduction were lower differentiation, depth of infiltration. The non - related factor with E - cadherin expression reduction were the lymph node metastasis and TNM stadium gastric cancer cell.4. The expression of COX -2 was significant related with that of MMP -9 and E-Cad(p<0.01).Conclusionsoverexpressions of COX - 2, MMP - 9 and declining expressions of E - Cad were detected in gastric cancer and the expressions were significantly related to the gastric cancer invasion and metastasis. The expression of COX -2 has sig-

Related Dissertations

  1. Expressions of PRL-3 and p27 in Gastric Carcinoma and Their Clinical Significance,R735.2
  2. Retrospective Analysis of 648 Cases of Gastric Carcinoma,R735.2
  3. Expression of TNF-α, MMP-9 and VEGF in BALF of Rats with Emphysema and Their Mutual Relationship,R563.3
  4. Influence and Significance of MMP-2 and VEGF of Hemangioma Endothelial Cells in Vitro Culture by Propranolol,R739.5
  5. The Regulation and Significance of NHE1 in Acidic Micro-environment of Gastric Carcinoma,R735.2
  6. Osteopontin through the MAPK signaling pathway and increased MMP9 expression correlation with embryo implantation,R321
  7. Expression of Transcription Factor T-bet in the Gastric Carcinoma Tissues and Its Correlation with Prognosis,R735.2
  8. Effects of Proliferation and Apoptosis of Gastric Carcinoma Cell Line Sgc-7901 by Cetuximab (Erbitux),R735.2
  9. Effects of Proteasome Inhibitor MG-132 on the Proliferation and Apoptosis of Human Colon Cancer HCT-116 Cell,R735.35
  10. The Study of Matrix Metalloproteinases-9 and Immunologic Function in Pediatric Patients with Asthma,R725.6
  11. Experiment Studies on the Effects of MMP-2 Expression Induced by Titanium Particles in MC-3T3-E1 Cells in Vitro,R687.4
  12. Studies of Different Therapeutic Methods on Airway Inflammation and Remodeling in the Mice Asthmatic Model,R725.6
  13. Study on Methylation of the Tumor Suppressor Gene in Epstein-Barr Virus-associated Gastric Carcinoma,R735.2
  14. The Function Study of the Tumor Suppressor Gene CDX2 in Gastric Cancer,R735.2
  15. Body mass index and gastric cancer , colorectal cancer -related research,R735.2
  16. The Expressions of SNCG and MAP2 in Gastric Adenocarcinoma and Their Clinical Significances,R735.2
  17. The Changes of MMP-2 Expression in Posterior Pole Sclera of Exogenous TIMP-2 Gene-transferred form Deprivation Myopia Guinea Pigs,R778.11
  18. Application of Decellularized Valves Modified by Matrix Metalloproteinase-2 Degradable Poly-ethylene Glycol Hydrogel in Tissue Engineering Heart Valve,R318.08
  19. The Expression and Significance of MicroRNA-151 and RhoGDIA in the Gastric Cancer,R735.2
  20. The Expression and Clinical Significance of HIF-1α in Renal Clear Cell Carcinoma,R737.11
  21. Correlation between Expression of S100A4, Vascular Endothelial Growth Factor C and Lymph Node Metastasis and Prognosis in Gastric Carcinoma,R735.2

CLC: > Medicine, health > Oncology > Gastrointestinal Cancer > Gastric neoplasms
© 2012 www.DissertationTopic.Net  Mobile