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The Effect of Blocker of Gap Junction on Penumbra Following Cerebral Ischemia

Author: YangYiMin
Tutor: FengJiaChun
School: Jilin University
Course: Neurology
Keywords: Gap junctions Penumbra Focal cerebral ischemia Octanol
CLC: R743.3
Type: Master's thesis
Year: 2005
Downloads: 89
Quote: 0
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Abstract


In order to study focal cerebral ischemia and reperfusion in the penumbra area changes and gap junction blocker octanol penumbra area , by inhibiting gap junctions to explore the new method of treatment of cerebral infarction . Middle cerebral artery occlusion of prepared acute focal cerebral ischemia in animal models the Zea Longa method determination of neurological score ; HE staining observed by light microscopy the morphological changes of the brain tissue of rats in each group ; detected using immunohistochemistry connexin 43 expression change ; stained with toluidine blue , cresyl violet staining and image analyzer to measure the area of the penumbra . Focal cerebral ischemia apparent infarct , mainly in the parietal cortex and striatum, lesions were stepped necrosis of the central area and minor lesions penumbra . The two staining showed that the ischemia-reperfusion extend the range of the penumbra in the short-term , six hours of reperfusion largest , after the Penumbra range gradually reduced ; the octanol intervention group necrotic neurons decrease in the number of cells , edema , penumbra zone is significantly reduced as compared to the surgical control group ; groups connexin 43 expression was not significantly change . The following conclusions: middle cerebral artery occlusion method model of focal cerebral ischemia , ischemic area constant reperfusion time can be controlled accurately , an ideal method is the study of focal cerebral ischemia ; toluidine blue tar purple two staining , determination of penumbra constant ; cerebral ischemia connexin 43 expression had no effect ; ischemia-reperfusion the penumbra extend short-term , at 6 hours of reperfusion after penumbra range gradually reduced ; inhibition of gap junctions can significantly reduce the area of focal cerebral ischemic penumbra .

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CLC: > Medicine, health > Neurology and psychiatry > Neurology > Cerebrovascular disease > Acute cerebrovascular disease ( stroke)
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