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The Protective Effect of MG132 on the Liver after Ischemia Reperfusion Injury by the Activity of NF-kB in Rats

Author: JinShan
Tutor: HanXiChun
School: Jilin University
Course: Clinical
Keywords: Ischemia-reperfusion injury Liver Nuclear factor kB Proteasome inhibitor
CLC: R657.3
Type: Master's thesis
Year: 2005
Downloads: 74
Quote: 0
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Abstract


Hepatic ischemia-reperfusion (I / R) injury in liver transplantation or the complicated liver resection poor postoperative liver function of important factors . Preventing hepatic I / R injury is a need to address the problem of liver surgery . This study investigated the protective effect on the liver in hepatic I / R injury of the proteasome inhibitor MGl32 in nuclear factor kB -mediated pathological processes . Through the establishment of the part of the animal liver ischemia reperfusion injury model to observe the change of liver histology , to detect liver function enzymology in liver tissue myeloperoxidase (MP0) content application sABC of immunohistochemical methods Determination of the activation of the nuclear factor kB level. Results: normal surgery control group liver tissue morphology , nuclear factor kB no activation , liver function, enzymology and the MPO normal level ; disordered arrangement of liver cell cord ischemia group and the I / R group , hepatic sinusoids and central veins varying degrees of congestion hepatocytes and endothelial cells in general edema deformation , nuclear factor kB activation , enzymology and MPO levels increased ( p lt ; 0.01 ) , which the I / R group significantly ; the application MGl32 liver enzymes and MP0 change alone similar to the ischemia group (p gt; O.05), but significantly lighter than the I / R group ( p lt; 0.01 ) . Conclusions obtained from the experiment when hepatic I / R , nuclear factor kB activation hold tissue infiltration of neutrophils , and thus the release of oxygen free agent , a proteolytic enzyme , and a peroxidase damage liver tissue , while the proteasome inhibitor MGl32 can reduce nuclear factor kB activation , reducing liver damage, protect the liver function .

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CLC: > Medicine, health > Surgery > Of surgery > Abdominal surgery > Liver and liver tube
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