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Experimental and Clinical Study of Alzheimer Disease on Positron Emission Tomography: Localization of Beta-Amyloid Plaques in Vivo

Author: Guo
Tutor: ZhangJinMing
School: PLA Postgraduate Medical School
Course: Medical Imaging and Nuclear Medicine
Keywords: Alzheimer’s disease (AD) Vascular dementia(VD) Positron emission tomography(PET) [18F]FDDNP β-Amyloid Imaging in Vivo [18F]FDDNP
CLC: R749.1
Type: Master's thesis
Year: 2005
Downloads: 87
Quote: 0
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Abstract


[PURPOSE]1 、 A method was studied for automated synthesis of 2-(1-{6-[2-[18F]Fluoroethyl]（methyl）amino}-2-naphthy)ethylidene)malononitrile ([18F]FDDNP) as senile plaques imaging with high synthesis yield in short time with a chemical process control unit （CPCU）, and the[18F]FDDNP distribution was researched in mice and monkey.2、 To evaluate the value of [18F]FDDNP PET imaging in patients with Alzheimer Disease （AD）,as well to differential diagnosis AD and Vascular dementia （VD）using PET. [Methods]1 、 18F ion was reacted with precursor 2-（1-{6-[2-Tso-ethyl]（methyl）amino}-2-naphthy）ethylidene)malononitrile （DMTEAN）. The residue was transported to a column. [18F]FDDNP was absorbed on the column, purified by water. [18F]FDDNP was eluted from column with small volume ethanol. The mice were sacrificed, taken out brain and others tissue, weighted tissue and radiocounted.2、 3 groups of subjects under strict clinical screening,7 AD patients in group one,6 VD patients in group two and 6 healty control subjects in group three.Immediately after [18F]FDDNP administration, Sequential emission scans were obtained in 3 of 6 healty control subjects and 1 AD patient using the following scan sequence :six 30-sec.scans,four 3-min.scans,five 10-min.scans,and three 20-min.scans, and a whole body PET scan; for other subjects Sequential emission scans were obtained at 5 min 25 min and 45 min after [18F]FDDNP administration. Using visual analysis to summarize the characteristics of each group.using Region of Interest （ROI） method to drow up each lobe of the cortex and the nerve nucleus under subcortical areas,then

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