Dissertation > Excellent graduate degree dissertation topics show

Design, Synthesis and Antitumor Activity of thalidomide derivatives

Author: ChenXiaoQing
Tutor: LiGang
School: Nanjing Normal University
Course: Microbial and Biochemical Pharmacy
Keywords: thalidomide synthetic and design Du145 anti-tumor activity
CLC: R965
Type: Master's thesis
Year: 2011
Downloads: 18
Quote: 0
Read: Download Dissertation


The rescent mechanism and pharmacological studies on the actions of Thalidom-de were reviewed in this dissertation.Thalidomide was selscted as a lead-compound for structural modification according to characteristics of it’s chemical structure and pharmaceutical activities. With 4-Pipradrol and halogeno-arene as starting materials,16 target compounds was obtained by Ullmann reaction, Mitsunobu reaction and so on,which have not been reported in the literatures.Thestructures of those compounds were confirmed by 1H-NMR,MS and IR.The pilot study of the anti-tumor property was carried out by Du145 cell line,with Doxorubicin as positive control.The results of the experiment on Du145 showed that most of target compounds have no activities.In order to observe the anti-tumor effects of target compounds significantly, other tumor cell line should be tried.

Related Dissertations

  1. Atovaquone analogues Design, Synthesis and antitumor activity of,R914
  2. Design, Synthesis and Biological Evaluation of Novel Podophyllotoxin Derivatives as Antitumor Agents,R284
  3. Design, Synthesis and Antitumor Activities Study of Quinoxaline-1,4-dioxide Derivatives,R914
  4. The Experimental Study of Semiconductor Laser Radiation and 5-FU Sustained Release Repressed Oral Malignant Tumor Cell,R739.8
  5. Effect of Thalidomide on Cellular Growth and Angiogenesis of Human Pancreatic Carcinoma Cell Line SW1990,R735.9
  6. Synthesis and Antitumor Activity of Phytosterol Derivatives and Synthesis of γ-Mangostin Derivatives,TQ464
  7. Asymmetric Synthesis of Two Fragments of Clavulactone, a Natural Marine Diterpenoid Having Antitumor Activity,TQ463.5
  8. Group A Streptococcus intracellular effective substances Purification and analysis of structure and activity,R915
  9. Studies on the Isolation, Identification, and Antitumor Bioactivities of Fucoxanthin in Algae,R285
  10. The Study of Blood Vessel and Tissue Injured by Anti-angiogenic Drugs Basing on Raman Spectroscopy,R730.5
  11. Studies on Synthesis and Anticancer Activity of Iodo-bridged Binuclear Platinum Complexes in Vitro,R96
  12. The Approach of Anti-tumor Mechanism of the Combination of Zedoary Turmeric Oil and Thalidomide in Lewis Transplantation Tumor,R734.2
  13. Inhibition of Vascular Endothelial Growth Factor Over-Expression on Influences of Malignant Transformation of Hepatocytes by Thalidomide,R735.7
  14. Study on Active Components of Morinda Citrifolia L,R284
  15. Synthesis and Biological Activities of LongistyleC Derivatives,S529
  16. Aminopeptidase inhibitor design and synthesis and activity of,R96
  17. The Effect of Thalidomide on Serum VEGF in Patientswith Non-hodgkin Lymphoma and Their Clinical Significance,R733.1
  18. Effects and Mechanisms of Chemical Constituents from Daphniphyllum Alkaloids on Anti-cancer Activity in Vitro,R285
  19. Asymmetric 1,5 - diaryl -1 ,4 - pentadiene -3 - ketones Synthesis and biological activity of,O623.522
  20. Euphorbia Euphorbia ebracteolata chemical and bioactive constituents,R284

CLC: > Medicine, health > Pharmacy > Pharmacology > Experimental Pharmacology
© 2012 www.DissertationTopic.Net  Mobile