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Modern medical research shows that the body of all life phenomena rely on the information transfer and regulation of the intracellular and extracellular messenger role of these processes inside and outside the cell , and as a second messenger cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) has a variety of physiological and pathophysiological role . And occupies an important position in the regulation of the immune response , cell proliferation, differentiation , and maintenance of smooth muscle contraction and relaxation balance , stable environment within the blood vessels involved in neural activity , regulation of gene expression . Respiratory diseases , more cyclic nucleotides with asthma , lung cancer , chronic obstructive pulmonary disease , pulmonary heart disease , idiopathic pulmonary fibrosis (IPF) has not been reported . To this end , we have adopted the radioimmunoassay detection IPF patient plasma cyclic nucleotide levels , compared with normal control subjects . Was found to IPF patient plasma cAMP decreased cGMP levels increased , a significant difference ( P lt; 0.05 ) compared with normal subjects . Also found that the reduction in of cAMP and cGMP rise in patients with IPF lung function , severity , hormone treatment , suggesting that detection of cyclic nucleotides important for the assessment of patients with IPF illness and hormone treatment effect for IPF patients with exogenous cAMP antifibrotic therapy to provide an objective basis .
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