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The Significance of LIGHT Expression in the Lungs of Mice Pulmonary Fibrosis Models

Author: HuYuXin
Tutor: MaZhongSen
School: Jilin University
Course: Internal Medicine
Keywords: Interstitial lung disease LIGHT T lymphocytes
CLC: R563.9
Type: Master's thesis
Year: 2005
Downloads: 66
Quote: 0
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Abstract


Purpose and methods : SiO2 suspension airway perfusion produced a mouse model of pulmonary fibrosis , 3d , 1w, 2w, 4w, 8w, 12w and 16w mice were killed using RT-PCR method of lung and spleen LIGHT changes in gene expression levels , and focuses on the significance of its expression in the lungs . Results: (1) pathological the : ① saline control group ( group 1-7 ) : Group 1 visible mild pulmonary edema ; remaining group of normal lung tissue structure . ② Model group (1-7 groups) : alveolar interstitial inflammatory cells (mainly macrophages and lymphocytes) infiltration, the more the number of lymphocytes in early inflammation is gradually decreased while the number with the progress of lung fibrosis , alveolar gradually collapse , gradually widened alveolar septa , gradually increased collagen deposition associated with fibroblast proliferation . (2) RT-PCR: the inflammation early ( group 1 ) , lung and spleen LIGHT gene expression levels were increased , which has significant . Group 2 ( inflammation 7 days) part of the lung in the exploration and LIGHT gene expression , exploration and partial splenic LIGHT increased gene expression ; 3-7 the level of expression of the of LIGHT gene in lung and spleen compared with the corresponding control group no significant change . Conclusion: The production of silica pulmonary perfusion lung fibrosis model method is simple , reliable , slow onset of pathological changes with IPF and other interstitial lung disease similar . Increased the LIGHT gene in lung inflammation early expression of activated T cells , initiates inflammation , and the release of inflammatory mediators , expand the inflammatory response and participation lung injury . Therefore , LIGHT gene is a major inflammatory reaction starts and the important factors involved in early lung injury . Spleen in normal physiological conditions , although a small amount of LIGHT gene expression , but does not cause pulmonary inflammation and fibrosis .

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CLC: > Medicine, health > Internal Medicine > Respiratory system and chest diseases > Pulmonary disease > Other
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