|
Objective: by measuring coronary microvascular spasm angina (Coronary Microvascular Spasm Angina CMSA) in the blood of patients with endogenous NO synthase inhibitor - asymmetric dimethyl arginine ( ADMA ) , nitric oxide ( NO ) , endothelin - 1 ( ET - 1 ) , superoxide dismutase ( SOD ) , malondialdehyde ( MDA ) and other indicators , and in patients with coronary heart disease (CHD) group , the control group to compare , trying to explore Ming the CMSA mechanism to provide experimental basis for clinical treatment . Methods: collected in our hospital in June 2002 February 2005 inpatients diagnosed as the CMSA patients 20 cases , the diagnostic criteria of typical chest pain , positive exercise test , normal coronary arteries , normal X - ray and echocardiography , and the exclusion of hypertension, diabetes, hypertrophic cardiomyopathy and other diseases . According to the results of coronary angiography , coronary single or multiple stenosis in 20 cases, more than 70% as coronary heart disease group . And 20 cases by age , sex matched healthy controls . All candidates venous blood determination of ADMA, NO, ET-1, SOD, MDA, blood lipids, blood glucose and fibrinogen and other indicators , and compare them. Results: (1) Compared with normal control group , CMSA group ADMA , ET - 1 level was significantly higher NO levels were significantly reduced , respectively, 5.60 ± 1.79 vs 1.01 ± 0.05,70.96 ± 16.05 vs 50.58 ± 7.52 ; 52.8 ± 7.59 VS 75.6 ± 18.3, P LT ; 0.05 , ADMA and ET-1/NO of showed a significant positive correlation ( r = 0.709 ) . And coronary heart disease group , no significant difference. (2 ) compared with the control group , the CMSA group SOD decreased and MDA increased , respectively ( 70.3 ± 17.8 vs 104.2 ± 18.8 , 6.25 ± 0.79 vs 4.09 ± 0.58 , P lt ; 0.05 ) ; coronary heart disease In comparison , no significant difference. ( 3 ) coronary heart disease , blood lipid ( TC , TG , LDL , HDL - C , Lpa ) level of the majority of abnormalities, significantly higher or lower than the CMSA group and normal control group , blood glucose and fibrinogen levels , no difference . Conclusion ( 1 ) CMSA patients with significant coronary vascular endothelial dysfunction, and endothelial dysfunction endogenous NO synthase inhibitor ADMA . ( 2 ) CMSA blood of patients with increase of MDA , SOD decreased ; suggests that oxidative stress plays an important role in the pathogenesis of CMSA .
|