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The Expression of IRP2mRNA、FnmRNA、TfRmRNA in Rat Brain with Iron Deficiency Anemia

Author: LiHuaiZhou
Tutor: AnYuHui；LiuYuFeng
School: Zhengzhou University
Course: Biochemistry and Molecular Biology
Keywords: Ferritin Receptor Iron regulatory protein Iron metabolism Iron deficiency anemia Rats mRNA
CLC: R55
Type: Master's thesis
Year: 2005
Downloads: 118
Quote: 0
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Abstract


Iron is one of the body's vital nutrients , iron deficiency can lead to a variety of body metabolism disorder , affecting the normal function of the body . The study shows that the normal body iron metabolism in transferrin receptor ( transferrin receptor , TfR) the ferritin ( Ferritins Fn) , iron regulatory protein (iron regulatoray protein, IRP) iron metabolism regulation under the combined effect of the protein molecules while in a state of dynamic equilibrium , wherein the post-transcriptional expression of the transferrin receptor and ferritin governed iron regulatory protein level adjustment . Brain as Senior nerve , directing and coordinating movement and life activities of the body 's nerve cells of the brain is particularly dependent on aerobic metabolism , and iron is a key component of the heme protein cytochrome , in the process of cellular respiration mediate mitochondrial electron transfer; same time, iron is also involved in the transition catecholamine tyrosine hydrogenases and monoamine oxidase constituting the process is the cofactor of the BRAIN many unique enzyme systems . Therefore, iron metabolism is extremely important for the functional activity of the brain tissue . Main proteins involved in iron metabolism in the brain tissue expression , however , its distribution in the brain tissue and the adjustment mechanism is not yet clear . This study was designed to establish the rat nutritional iron deficiency anemia in animal models on the basis of the different regions of the brain the IRP in 2 mRNA , FnmRNA , TfRmRNA the expression detection , preliminary investigate the missing gene level iron anemia animals in different brain regions of iron metabolism . Methods: 40 healthy adult Wistar rats were randomly divided into 2 groups namely the control group and the deficient group , reference LIAO Qing-Kui proposed the establishment of iron deficiency animal models . Iron deficiency rats have appeared about 15 days to about 60 days to iron deficiency and varying degrees of iron deficiency anemia . Be grouped according to the SI, sFn, Hb measurement result , SI, and SFN

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