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The brain Zhixinkang capsule in treating ischemic stroke recovery ( qi deficiency and blood stasis and phlegm obstruction ) clinical study

Author: FangZuoZuo
Tutor: TuJinWen
School: Hubei College of Traditional Chinese Medicine
Course: Chinese medical science
Keywords: Ischemic stroke TCM therapy Clinical Research Yiqihuoxue Of brain Zhixinkang capsule
CLC: R255.2
Type: Master's thesis
Year: 2006
Downloads: 73
Quote: 0
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Abstract


Purpose to observe brain Zhixinkang capsule of ischemic stroke (cerebral infarction) Qi and Blood Stasis phlegm obstruction convalescent patients efficacy, safety, and the the step Naoxintong capsule as control and explore its efficacy mechanism for clinic application to lay a foundation. Method 1. Clinical data in all cases the Department of Hubei Province Traditional Chinese Medicine Hospital of Neurology outpatient and hospitalized patients in November 2004 April 2005, a total of 46 cases, randomized, double-blind, positive controlled method is divided into a treatment group and a control group. Including treatment group, 22 patients in the control group of 24 cases. Two groups in age, gender, disease duration, and signs on the basic balanced by the statistical test, there was no significant difference (P> 0.05), comparable. 2. Drug usage treatment group: the brain Zhixinkang capsules, 0.4 g / tablets. Control Group: the step Naoxintong capsule, and 0.4 g / tablets. The two drugs are each 4 3 times a day, half an hour after meals with warm water to swallow. The treatment of 28 days, the observation period, the follow-up once every two weeks, the two groups of patients during treatment to stop taking the treatment of cerebral infarction drugs and drugs that may affect the observed results. Maintain adequate sleep while Zhu Huanzhe during treatment to avoid mental stimulation, light diet, avoid Feigan the thick greasy food and spicy food, avoid smoking and drinking. 3. Security observed two groups of patients in the first 29 days after the first visit on the first day and treat each hematuria fecal routine, liver and kidney function, ECG, blood coagulation time (prothrombin time, prothrombin time, prothrombin time normalized ratio, some activated thromboplastin time), changes in blood flow (high cut, low cut, whole blood viscosity, plasma fibrinogen) detection. And newly diagnosed the first average daily do a head CT. 4. The efficacy assessment of patients in both groups 15, 29 days after the first visit on the first day and treatment records once TCM syndrome and signs score and neurological deficit scores, patients living skills state and for statistical analysis. 5. Statistical methods to count data with x ~ 2 test, t test measurement data, ranked data Ridit test. Results 1. Clinical Comparison: treatment group, eight cases markedly effective in 12 cases, 2 cases, the total effective rate was 90.91%; control group, six cases markedly effective in 14 cases, 4 cases, the total effective rate of 83.33%. After statistical analysis, the two groups was no significant difference (P> 0.05). Brain Zhixinkang Capsule step Naoxintong capsule has a good effect on patients. 2. The TCM syndromes comparison: treatment group, 3 cases markedly effective in 18 cases, and 1 case, the total efficiency of 95.46%; control group, 2 cases markedly effective in 20 cases, 2 cases, the total effective rate was 91.67%, the statistical analysis There was no significant difference (P> 0.05). Brain Zhixinkang Capsule step Naoxintong capsule significant effect on TCM syndrome. 3. Neurological deficit scores comparison: the two groups after the treatment, the degree of neurological deficit scores than before treatment significantly reduced, there was a significant difference (P <0.01). Rated the degree of change in the treatment group and the control group showed no significant difference (P> 0.05). Brain Zhixinkang Capsule step Naoxintong capsule clinical neurological deficit improved significantly effect. 4. Changes in blood flow changes in comparison: before and after treatment, high shear whole blood viscosity, fibrinogen changed very significant difference (P <0.01), low-cut decrease was significant (P <0.05), the full treatment group blood viscosity is high cut, low-cut with the control group after treatment, compared to a very significant difference (P <0.01). Say

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CLC: > Medicine, health > Chinese Medicine > TCM Internal Medicine > General Syndrome > Stroke
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