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Objective: to study the extracted from skin slag winery to Oleanolic acid, Oleanolic acid, OA) as the main efficacy composition of grape skin extract, grape seed oil as solvent, the preparation of a kind of protect liver, lipid-lowering effect the feasibility of soft capsules. Methods: (1) in grape skin extract as main ingredients, soft capsule prescription screening, determine the preparation technology. (2) OA levels were determined by HPLC method, through accelerated test, the preliminary observation preparation stability. (3) through a high-fat mouse model and carbon tetrachloride (CCl < sub > 4 < / sub >) on acute liver injury model mice, the preliminary observation of soft capsule lipid-lowering, protect liver function. Results: the extracts from grape skins and grape seed oil could be successfully soft capsule preparation. Medium and high dose group can reduce hyperlipidemia model rats serum triglyceride (TG), high dose group could increase serum high-density lipoprotein (HDL); Middle, high dose group can decrease liver injury model of rat serum alanine aminotransferase (ALT) and aspertate aminotransferase (AST), but the pathological characteristics of no significant improvement. Conclusion: grape skin residue as raw material preparation of soft capsule of the nature of the reasonable prescription design, preparation stability; At the same time, the preparation may have certain regulation of blood lipids, have good market prospects for development.
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