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Objective: To explore the sepsis rat cortical evoked potential changes in different brain regions of iNOS , c - Fos protein expression , and dexamethasone (DXM) intervention effect . Methods: 88 healthy adult Wistar rats were randomly divided into CLP ( cecal ligation and puncture ) group , DXM ( 10mg/kg) treatment group and the control group , observed 1h, 2h, 4h, 6h, 10h different times of the cerebral cortex evoked potentials of the dynamic changes in the organization of different brain regions ( cerebral cortex , hippocampus, hypothalamus ) iNOS , c - Fos protein expression using immunohistochemistry methods . Results: control rats leads CEP wave in a mainly positive waves in composite wave . An incubation period of P1 wave CLP10h group compared with the control group significantly longer ( P <0.05 ) , volatility significantly lower (P <0.05); dexamethasone 1h intervention group with CLP1h group of comparison , and the P1 latency compared significantly reduced ( P <0.05 ) volatility whom showed no significant differences . Dexamethasone 10h intervention compared group with CLP10h group P1 wave latency compared significantly reduced (P <0.05), volatility increased significantly ( P <0.05 ) . The cerebral cortex , hypothalamus region of iNOS protein in CLP4h , CLP6h CLP10h , DXM10h groups and the control group compared expression were significantly increased (P <0.05). DXM6h group , DXM10h group with the corresponding CLP6h group the , CLP10h group compared iNOS protein expression was significantly higher (P <0.05). Hippocampus of iNOS protein in CLP6h the CLP10h group and the control group expression was significantly higher ( P <0.05 ) . The organization of the cerebral cortex, hippocampus , c-Fos started in CLP1h express increased expression gradually increased with time and continued to 10h after treatment ; each group compared with the control group expression were significantly increased ( P <0.05 ) . Group of DXM1h , DXM2h group corresponding CLP1h of group the , CLP2h group compared to c-Fos protein expression was significantly higher (P <0.05). The next the the hypothalamic area DXM1h group , DXM2h group with the corresponding
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