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Objective: To study the first part of the retinal pigment epithelial degeneration model of retinal degeneration disease is a group caused by RPE and photoreceptor cell degeneration and apoptosis severe blinding eye diseases , Currently, the complexity of the pathogenesis of these diseases , the cause is unknown , there is no mature and effective method of treatment. In recent years, studies have shown that retinal transplantation is the closest to the clinical application of the method for the treatment of advanced retinal degenerative diseases , and application of animal models to study transplantation essential means . Therefore, this study pigmented rabbits for the study, and by comparison of laser photocoagulation and intravenous sodium iodate two kinds of the induced pigment epithelial degeneration method to find the appropriate modeling approach and observe retinal pigment epithelial degeneration model in retinal morphology and functional characteristics . Method : 1 laser photocoagulation colored rabbit 12 , were randomly divided into four groups , each group of three rabbits , six eyes . Normal control group, the experimental ( 1 ) group ( 1 photocoagulation spots ) , experimental group 2 ( 1 to 2 photocoagulation spots ) , experimental group ( 2 photocoagulation spots ) . Experimental group each eye to view nipple myeloid line vertical myeloid line nipple too , as the vertical line as the boundary is divided into four quadrants , each quadrant were grouped by the krypton laser processing , 1,3,5 days after the removal of the eye by light microscopy and electron microscopy changes in the retina . Intravenous sodium iodate method : select adult health 32 64 eye eye disease pigmented rabbits were randomly divided into four groups , each group of eight 12 eyes , respectively, for the control group ,
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