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Cnidium for the Umbelliferae snake bed case of the plant Cnidium Cnidium monnieri ( L. ) Cuss mature dry fruit , \impotence, cold uterus , infertility , cold vaginal discharge , wet nose , lower back pain ; outside the governance of the vulva eczema , vaginitis . Civil topical prescription for anti-fungal , anti-viral , deworming and treatment of eczema and vaginal itching . The the Cnidium contain osthole , borneol iso- valeric acid ester , Isobornyl Europe decursin , snake bed set , bergapten different the fennel prime ( different saxifrage prime ) , of xanthotoxin xanthotoxol and Angelica esters and other active ingredients , the where osthole (osthole, ost) as its main active ingredient content of up to about 0.8% , or 60% of total coumarins . Since the 1980s , at home and abroad on osthole mainly focused on the pharmacological effects , mainly antihypertensive effect , inhibition of the heart , learning memory to promote the role of sex hormone -like effects , regulation of bone metabolism , enhance immunity effect . How to absorb the active ingredients of drugs in the body , distribution , metabolism, excretion guiding significance for the clinical application of the drug , and the study of the drug in the body is a prerequisite of rational drug use . Pharmacokinetic study at home and abroad on osthole than its predecessor , this project aims to further study osthole dynamics in the animal 's metabolism , the laws of the tissue distribution and excretion of law , plasma protein binding rate , metabolites and the impact of drug-metabolizing enzymes for the the further osthole clinical trials research basis . Subject to reversed-phase high performance liquid chromatography as a means of detection , the establishment of a New Zealand white rabbit and rat plasma , tissue ,
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