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Studies on Effects of Porcine Selenium Toxicity on Immune Function of Erythrocyte

Author: ZhouHuiPing
Tutor: GuoDingZong
School: Huazhong Agricultural University
Course: Clinical Veterinary Medicine
Keywords: Pig Erythrocyte immune Selenium Chronic selenium poisoning
CLC: S858.28
Type: Master's thesis
Year: 2005
Downloads: 205
Quote: 2
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Abstract


2-month-old weaned castrated piglets 15 randomized into three groups : control group , the selenium group , selenium copper group , n = 5 . To investigate the effect of selenium on the immune function of pig erythrocytes , measured chronic selenium poisoning piglet serum selenium, serum glutathione peroxidase (glutathione-peroxidase, GSH-Px) activity, erythrocyte Section Ⅰ complement receptor ( C receptors 3b C 3b R ) rosette rate and red blood cells (immune complex, IC) rosette rate and serum ( red cell immune adherence to particular styles RCIA ) promote the rate and inhibition rate . The purpose of this test is to provide a theoretical basis for the study of selenium on the pig erythrocyte immune function in order to reveal the pathogenesis of the disease . The results show as follows : 1 plus selenium group serum selenium content increases in the 30 ~ 40d differences significant with ( P lt ; 0.05 ) , 50 ~ 60d difference extremely significant with ( P lt ; 0.01 ) , the group of GSH-Px activity increased in 10 ~ 30d difference was very significant (P lt; 0.01), followed by decline , highly significant differences in 60d compared with the control group ( P lt; 0.01 ) . Se copper group serum selenium content difference is not significant ( P gt ; 0.05 ) , the group of GSH-Px activity first rise in the difference of 20 ~ 30d extremely significant with ( P lt ; 0.01 ) , 40 ~ 60d differences are not significant with (P gt; 0.05). 2 . Selenium group RBC - C 3b R garland the first rise , after a significant decline in 30d differences ( P lt; 0.01 ) , plus selenium copper group difference was not significant (P gt ; 0.05) . IC rosette rate plus selenium group and addition of selenium, copper group are the difference was not significant ( P gt ; 0.05 ) . The 3 plus selenium group serum RCIA garland promote the rate of decline in the 30 ~ 60d Exclusive extremely significant with ( P lt ; 0.01 ) , while the group of serum RCIA garland inhibition rate rise , the difference of 20 ~ 60d extremely significant with ( P lt ; 0.01 ) . Se copper serum RCIA garland promote the rate of decline , the difference of 30 ~ 60d extremely significant ( P lt ; 0.01) , the group serum RCIA garland suppression rate difference was not statistically significant ( P gt ; 0.05) . Comprehensive analysis shows : throughout the trial period , erythrocyte immune function higher first With the deepening of selenosis , erythrocyte immune function decline was inhibitory state that with time , excessive amounts of selenium in the body metabolism constantly consumed exclude the reduce or redistribution in vivo red blood cell immune function .

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CLC: > Agricultural Sciences > Livestock, animal medicine,hunting,silkworm,bee > Animal Medicine ( Veterinary Medicine) > Livestock, poultry, wildlife diseases > Livestock > Pig
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