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[Objective] To detect chronic HBV carriers peripheral blood T cell subsets , and patients according to age at different intervals packet to identify the patient's condition and the cellular immune function of turning point , proven carriers increased with age by the immune tolerant phase into the immune the mechanism of the active period . 【Methods】 104 cases of chronic HBV carriers peripheral blood T cell subsets in healthy controls compared to 40 cases detected . 5 -year-old , 10-year-old , 20-year-old intervals chronic HBV carriers grouped hepatitis B e antigen (HBeAg) -positive rate and T cell subsets were compared between the age groups . 【Results】 chronic HBV carriers and healthy control CD3 ( F = 5.976 , P = 0.016 ) , CD4 (F = 46.244 , P = 0.0001 ) , the ratio of CD4/CD8 ( F = 254.357 , P = 0.0001 ) decreased , CD8 (F = 103.848, P = 0.0001) increased . Chronic HBV carriers CD8 (F = 6.726, P = 0.011) T cells significantly decreased in the 30-year-old . Chronic HBV carriers, 30-year-old e antigen -positive group than the negative group CD4 ( F = 11.123 , P = 0.001 )
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