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Basic Pharmaceutical Researches on Radix Isatidis and Rhizoma et Radix Baphicacanthis Cusiae

Author: WuZuoQiu
Tutor: ZhangRongPing；ZouCheng
School: Kunming Medical College
Course: Medicinal Chemistry
Keywords: Banlangen North Banlangen South Banlangen Antibacterial activity Extraction Process Quality Control Chemical composition
CLC: R282
Type: Master's thesis
Year: 2005
Downloads: 375
Quote: 4
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Abstract


[Objective] carried out a comparative study of the North Banlangen (Radix Isatidis) South Banlangen (Rhizoma et RadixBaphicacanthis Cusiae). [Content] This thesis explores two Banlangen pharmacological activity, the active ingredient extraction technology and quality control indicators, three aspects of the chemical composition of the active site. [Method] 1. Disc agar diffusion method were measured polar fractions of the South, North Banlangen extract Candida antibacterial activity against Staphylococcus aureus, Bacillus, E. coli, and white, two Banlangen different polar fractions antibacterial strength, and its activity is determined by agar dilution method strongest parts of the minimum inhibitory concentration (MIC). Using the boiled alcohol precipitation method and system solvent on the South, North Banlangen extract antibacterial activity as a pharmacodynamic indicators to measure the pros and cons of the two extraction methods, and suitable for the production of two Banlangen preparations The active ingredients of the extraction process and quality control indicators to explore. 3 South, North Banlangen system solvent extraction, to extract repeated separation and purification of the active site, the use of physical and chemical methods and modern spectral analysis technology (MS 1 HNMR 13 < / sup> CNMR) identification of the resulting compound structure. [Results] 1 South, North Banlangen have broad-spectrum antimicrobial effect, North Banlangen concentration of active ingredients in the polar and higher parts of South Banlangen the active ingredient dispersed in various polar fractions. The two most active parts are ethyl acetate, methanol extract of the 8 components, the component of the South, North Banlangen Staphylococcus aureus MIC were 0.125mg/mL and 0.25 mg / mL against E. coli MIC were 0.25mg/mL and 1mg/mL. Two Banlangen pharmacodynamics. Boiled alcohol precipitation extraction process was significantly lower than the result of processing by the system solvent method, system solvent can be enriched in active ingredients to improve efficacy. The single active ingredient are not suitable for Quality Control. Separated from the South Banlangen identified 12 compounds, six of them for the first time from South Banlangen, is the first from Acanthaceae Coma blue genus. The first time the presence of flavonoids found in South Banlangen. Separated from the North Banlangen identified eight compounds, four of them for the first time from North Banlangen is the first genus from cruciferous Siong Blue. [Conclusion] South, North Banlangen in all aspects there are differences, to be studied in depth in order to be treated differently, reasonable application.

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CLC: > Medicine, health > Chinese Medicine > Of Pharmacy > Chinese herbal medicines
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