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The Experimental Study on the Protective Effect of Resveratrol in the Forepart of Spinal Cord Injury

Author: MeiHongJun
Tutor: LiuShiQing
School: Wuhan University
Course: Surgery
Keywords: resveratrol spinal cord injury Bcl-2 cytochrome C oxidase superoxide dismutase
CLC: R285.5
Type: Master's thesis
Year: 2005
Downloads: 80
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Abstract


Objective: To investigate the protective effect of resveratrol on the changes about the expression of Bcl-2/Bax and about the activity of SOD (Superoxide Dismutase) and COX (Cytochrome C Oxidase) in the forepart of spinal cord injury. Methods: 62 adult male Sprague-Dawley rats were randomly divided into five groups includig normal control group, mode control group, injury group, resveratrol treatment group and MPSS (Methylprednisolone Sodium Succinate) treatment group. After the modes of spinal cord moderate injury were established by the method of Allen, resveratrol (100mg/kg), methylprednisolone sodium (100mg/kg) or normal sodium was injected immediately by intraperitioneal injection. The changes about the expression of Bcl-2/Bax and about the activity of SOD and COX were observed on the resveratrol treatment group compared with the MPSS treatment group at 8, 24 and 72h after spinal cord injury. Results: The mean difference of the masculine cellular number about the expression of Bcl-2/Bax and of the activity about SOD and COX between on the resveratrol treatment group and on the injury group is significant (p<0.05) at 24 and 72h after spinal cord injury; And at 8h,the significance of the mean difference is displayed not on the the expression of Bcl-2/Bax and on the activity about COX (p>0.05) but on the the expression of Bax and on the activity about SOD (p<0.05) after the injection of resveratrol;which means that resveratrol has no more remarkable strongpoint than methylprednisolone sodium succinate.Conclusion: Resveratrol can promote the expression of Bcl-2 and restrain the expression of Bax. Furthermore,it can enhance the activity about COX and SOD. Therefore, resveratrol can expert the protection on the spinal cord in the forepart of spinal cord injury.

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