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The Morphologies, Structures and Properties of Bybrid Nanofibrous Scaffolds

Author: ZhaoMinLi
Tutor: YangXiaoPing；SuiGang
School: Beijing University of Chemical Technology
Course: Polymer Chemistry and Physics
Keywords: Polylactic acid Multi-walled carbon nanotubes Hydroxyapatite Nanofibers Electrospinning
CLC: R318.08
Type: Master's thesis
Year: 2006
Downloads: 320
Quote: 0
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Abstract


Preparation of the scaffold is one of the core technologies of tissue engineering research . Due to the different nature of the material , thus adopting a single material is difficult to meet the requirements of the tissue engineering scaffold composite to composite scaffold scaffold hot research new performance . In recent years due to the good biocompatibility of polylactic acid / hydroxyapatite (PLLA / HA) composite scaffolds , degradation of performance and osteoinductive properties making it ideal bone tissue scaffold . But this type of composite material in reinforced composite interface combination to adjust the rate of degradation of the material to improve the strength of the material still can not meet the requirements of an ideal scaffold for tissue engineering . Therefore, the need to study the preparation process , prepared electrospinning nanofibers its high porosity , pore size adjustable structure biocompatibility characteristics of a scaffold for tissue engineering research hotspot . Cells in less than itself (micron) diameter fibers having better adhesion properties . Therefore , the use of three dimensional cell scaffold can be prepared by electrospinning better bionic the structural features of the natural extracellular matrix , is expected to become the ideal tissue engineering scaffolds . In addition , the carbon nanotubes have a high surface energy and prominent mechanical properties , and can promote the adhesion between the cells and the composite material , and therefore nanotubes may be used as bone tissue scaffold effective enhancers . The experiment based on methylene chloride and methylene chloride and 1,4 - dioxane ring two-solvent system , the use of electrostatic spinning method prepared nanofibers of polylactic acid , polylactic acid / hydroxyapatite , polylactic acid / multi-walled carbon nano tube / hydroxyapatite hybrid nanofibers spinning solution concentration , spinning voltage , flow rate , and to accept the distance of process parameters on fiber morphology ; hydroxyapatite and satisfied

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CLC: > Medicine, health > Basic Medical > Medical science in general > Biomedical Engineering > General issues > Biomaterial
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