Dissertation > Excellent graduate degree dissertation topics show

Study on Microemulsion-based Organogels for Transdermal Drug Delivery System

Author: LinLiHua
Tutor: YangYaJiang
School: Huazhong University of Science and Technology
Course: Polymer Chemistry and Physics
Keywords: Molecular Gels Microemulsion Of Microemulsion molecular gel Viscosity Transdermal noisome
CLC: TQ460.1
Type: Master's thesis
Year: 2005
Downloads: 338
Quote: 3
Read: Download Dissertation

Abstract


Molecular gel is formed after the organic solvent or water by some small molecule organic compounds gelation having a viscoelastic semi-solid system. This type of system is a supramolecular structure has broad application prospects in the field of drug carrier. Studied Span 60, monostearate the glycerides (GMS), of tripalmitin (GTP) in isopropyl myristate (IPM) molecules formed in the gel. Experimental results show that: of Span 60 in the IPM in the self-assembled into the interconnected three-dimensional network structure by the rod small micro tube, GMS in the IPM entangled three-dimensional network structure to each other by small microsphere is formed in a tubular or spherical structure can be wrapped in water-soluble drugs. GTP in the IPM in a sheet-like three-dimensional network structure is formed. Determination of the shear viscosity of the gel system showed: Span 60 and GMS molecules formed gel, the shear viscosity with shearing time growth is reduced, restored the place for some time, its viscosity, indicating Span 60 and GMS the IPM molecule formed gel has certain rheological and thixotropic, this favorable rheological characteristics, its use as a transdermal formulation applicator. Add Tween 20 can greatly increase the viscosity of the gel system, increasing the concentration of the gelator can greatly improve the viscosity of the gel system. For the GTP the IPM molecule formed gel, with the growth of shearing time, the viscosity change is small, the weaker its thixotropy. Drug loading (triptolide as a model drug) stable microemulsion molecular gel release rate was zero order kinetics release, its per unit area of ??a transdermal delivery rate (J = 19.26ng · cm -2 < / sup> · h -1 ) ointment transdermal rate of 2.92 times. Both the structure of the non-ionic surfactant vesicles (niosome) still uses are similar to liposomes. This article using a rotary evaporator - ultrasonic dispersion prepared niosome, laser particle analyzer results indicate that the herein prepared blank niosome particle diameter is relatively small, at less than 500nm, and uniform distribution, and a polydispersity index from 0.2 -0.3. the absolute value of a niosome the surface potential (Zeta potential) the majority less than 30, good stability system. Add Tween 20 non-ionic surface active agent in the Preparation a niosome of hydration process, the particle diameter with the increase in the amount of Tween 20 GMS niosome gradually decreases, and stability first increased and then decreased.

Related Dissertations

  1. Effect of Limestone Powder on Properties of Concrete Mixture,TU528
  2. Study on Spinning of High Viscosity Polyamide-6/Rare Earth,TQ340.64
  3. Synthesis and Properties of Novel Low Viscosity Difluorooxymethylene-Bridged Liquid Crystals Compounds,O753.2
  4. Microemulsion containing drug delivery systems to promote intestinal absorption of octreotide,R943
  5. Preparation of ZnO -based microemulsion photocatalytic material,O614.241
  6. The Rheological and Adhesion Properties of EVA-based Hot Melt Adhesives,TQ436.4
  7. Study on the Preparation of New Rapamycin Solid Formulations and Their Pharmacokinetics in Rats,R965
  8. Complex biological agents on Culex Culex pipiens pallens Coquillett 4 instar larvae of toxic effects,R184
  9. Amino silicone microemulsion electrochemical wastewater pretreatment technology research,X703.1
  10. Hydroxypropyl cellulose fiber used as preparation and Solution Properties,TQ352
  11. Study on the Rheology of SBS Modified Asphalt and the Dose of SBS,U414
  12. The Pharmacokinetics Study on Brain Spiritual Microemulsion,R285
  13. Synthesis of NVF-DADMAC Copolymer and Its Application in Papermaking,TS727
  14. Application of Rhamnolipid Biosurfactant in Heavy Oil Viscosity Reduction,TE868
  15. Study on Interaction between Ionic Liquids and Surfactants & Application Research in Enhanced Oil Recovery,TE39
  16. Calculation of Thick Oil of Petroleum Reduction,TE624
  17. Syntheticism of Hydroxyl Acrylic Ester Emulsion Containing Phosphate Ester and Preparation of Water-dispersible Polyisocyanate,TQ630.4
  18. Synthesis of Poly (Butylene Succinate),TQ316.33
  19. Study on the Rhelolgecal Properties and Compatibility of Low-Concentration Carrageenan,TQ432.7
  20. Simultaneously Determine Metal Ion by Microemulsion HPLC,O657.72
  21. Immobilization of Cellulase by Nanotechnology with γ-Fe2O3 and PVA,Q814.2

CLC: > Industrial Technology > Chemical Industry > Pharmaceutical chemical industry > General issues > Basic theory
© 2012 www.DissertationTopic.Net  Mobile