|
Objective: a light microscope to observe the effect of the impact of alcohol on rabbit myocardial cell morphology changes and trimetazidine trimetazidine intervention . Observed alcohol rabbit plasma NO, SOD, MDA content and trimetazidine interfere with the effect of the treatment . 3 , the observation of alcohol on the rabbit cardiomyocytes proto-oncogene C- myc , C - fos expression and trimetazidine interfere with the effect of the treatment . The observed alcohol echocardiographic parameters in rabbits LVPWd , LVSd , LVDd , FS , EF , E and E / A ratio and trimetazidine effect of therapeutic intervention . 5 , to explore the relationship between the rabbit plasma enzyme , myocardial cellular oncogene gene expression and cardiac ultrasound parameters under the influence of alcohol and its significance . Explore under the influence of alcohol qumei trimetazidine on myocardial protective effect and its mechanism of action . Method 1 , grouping : 30 New Zealand rabbits were randomly divided into three groups , group I ( normal control group ) : normal feeding 30 days to do the ultrasound echocardiography , blood checks were sacrificed for pathological : Ⅱ group (fed alcohol group ) : on the basis of normal feeding fed alcohol for 30 days, echocardiogram , blood tests , were sacrificed for pathological ; III group ( treatment group) : on the basis of normal feeding fed alcohol and qumei he triazine (in fed alcohol one hour before fed trimetazidine ) 30 days to do the echocardiogram , blood tests , were sacrificed for pathological . 2 , the measured ultrasonic parameters : 25 ~ 30mg/kg anesthesia the rabbit intravenous injection of sodium pentobarbital , the fixed limbs supine board , wood left 30 ° tilt shaved Net chest hair , use the frequency 3.0MHZ probe
|