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The Expression of MDR Gene in Non-Small Cell Lung Carcinoma and Its Relationships with Smoking

Author: SunZhaoMing
Tutor: LiXiBo
School: Shandong University
Course: Thoracic Surgery
Keywords: Lung cancer MDR1 gene Smoke
CLC: R734.2
Type: Master's thesis
Year: 2005
Downloads: 68
Quote: 0
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Abstract


The purpose of lung cancer is one of the major diseases of serious harm to human health and life , the morbidity and mortality of the past 50 years only in the malignant tumor significantly increased year by year . The overall 5-year survival rate of lung cancer after surgery include multidisciplinary treatment , the 5-year survival rate is only about 33% , the prognosis is unsatisfactory . The high incidence and low survival rate of lung cancer promote the study of the molecular biology of lung cancer , in order to improve the prevention of lung cancer , early diagnosis and early treatment . Studies have shown that the formation and development of lung cancer is a multi-step process , a series of changes in bronchial mucosal hyperplasia to true tumor formation , cancer gene deletions and rearrangements of chromosome segment including the cellular level , the molecular level activation and inactivation of tumor suppressor genes and apoptotic genes is suppressed . Recent studies have shown that the multidrug resistance gene is lung cancer , in particular, the biggest obstacle for non-small cell lung cancer treatment , even more sensitive to chemotherapy - small cell lung cancer after several cycles of chemotherapy , the emergence of resistance , leading to treatment failure . In this study, by detecting the level of expression of the MDR gene in non-small cell lung cancer , and determine the MDR gene expression in non - small cell lung cancer and normal tissues and the relationship between smoking and lung cancer , lung cancer prevention , early diagnosis and gene therapy provide a theoretical basis . The methods randomly selected 36 cases diagnosed as lung cancer and surgical treatment of patients with intraoperative collection of lung cancer and normal lung tissue samples at -80 ℃ to save fresh tissue and 10% formalin-fixed specimens . Detailed records of each patient clinical data , including detailed preoperative smoking status and pathological features . Are divided into groups according to smoking status and the clinical and pathological features , using immunohistochemical SP method , the MDR gene expression levels in lung cancer tissue and normal lung tissue , and analysis of the MDR gene expression and clinical pathological features , clinical staging, cell differentiation extent of lymph node metastasis and smoking history . Compare with diverse experimental results statistically test measurement data using analysis of variance and t-test , multi- metering data relationship between

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CLC: > Medicine, health > Oncology > Respiratory system tumors > Lung tumors
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