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Platelet adhesion , aggregation and thrombosis is an important cause of ischemic cerebrovascular disease etiology . Generally believed that the interaction between platelets and vascular endothelium are important factors for thrombosis , platelet abnormalities functional intervention , has become one of the primary means for effective prevention and treatment of ischemic cerebrovascular disease . In the number of antithrombotic drugs , aspirin cost effective , fewer side effects and has been widespread concern . Aspirin mainly by inhibiting the metabolic pathways of arachidonic acid cyclooxygenase dependent platelet activation means , resulting in the inhibition of the thrombus formation . Platelet activation is a very complex process, the participation of a variety of receptors and the medium in the process of thrombosis in the activation reaction , release reaction , one of the arachidonic acid metabolic pathway is just one of the ways , and there exists the possibility of variation of metabolic pathways . To this end , has a different mechanism of action , able to multi- link antagonize platelet activation functions antiplatelet drugs , an important direction for Research and Treatment of antithrombotic drugs . Dipyridamole as phosphodiesterase inhibitors , which can activate adenylate cyclase , while reducing cAMP decomposition can increase the generation of cAMP , the formation of the inhibition of platelet activation . Dipyridamole and aspirin in different aspects of the suppression of platelet function and thrombosis , the theoretical basis of the two drugs . Aspirin and dipyridamole combination compound preparation in clinical practice has been used, the combination of the unilateral and compound preparation of conventional dosage forms , mainly unilateral dose specifications less the Compound Prescription unreasonable ( dipyridamole 25mg aspirin 75mg) , resulting in a synergistic effect is not ideal , as well as the corresponding side effects , so that the actual use subject to significant restrictions . According to the mechanisms and characteristics of the role of aspirin and dipyridamole , the study found that 100mg of dipyridamole and 12.5mg of aspirin in combination , and aspirin , absorption , 40 ~ 70min after
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